HP1 alpha (CBX5) Mouse Monoclonal Antibody [Clone ID: 1E8-5C3-10E1]

Specifications

Product Data
Clone Name	1E8-5C3-10E1
Applications	IHC, WB
Recommend Dilution	WB: 1/500-1000 IHC: 1/100-200
Reactivity	Human, Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant protein expressed in E.coli.
Isotype	IgG1
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	22kDa
Gene Name	chromobox 5
Database Link	Entrez Gene 23468 Human UniProt ID P45973
Background	Swiss-Prot Acc.P45973.Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Synonyms	HP1; HP1-ALPHA; HP1A; HP1Hs-alpha
Reference Data

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