Dynamin 1 (DNM1) Mouse Monoclonal Antibody [Clone ID: 5B9-5G3-6D2]

Specifications

Product Data
Clone Name	5B9-5G3-6D2
Applications	IHC, WB
Recommend Dilution	WB: 1/500-1/2000 IHC: 1/200-1/1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human Dynamin-1 expressed in E. Coli.
Isotype	IgG2a
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
Concentration	lot specific
Purification	Ascitic Fluid
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	97kDa
Gene Name	dynamin 1
Database Link	Entrez Gene 1759 Human UniProt ID Q05193
Background	Swiss-Prot Acc.Q05193.Dynamin-1 (Dyn1), with 864-amino acid protein (about 95kDa), belongs to the dynamin family. Dynamin-1 (neuron-specific), dynamin-2 (ubiquitously expressed), and dynamin-3 (expressed only in the Tis, brain, and lung), constitute the dynamin family. Members of the dynamin family are GPTase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin-1 is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C. Dynamin-1 is a large GTPase enzyme required in membrane constriction and fission during multiple forms of endocytosis. Dynamin-1 is also a key molecule required for the recycling of synaptic vesicles in neurons, and it has been known that dynamin-1 gene expression is induced during neuronal differentiation.
Synonyms	DNM
Reference Data

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