Phospho KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	IHC: 1/100-1/300 ELISA: 1/20000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of Thr246. AA range:191-240 (Phosphorylated)
Isotype	IgG
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Gene Name	potassium voltage-gated channel subfamily Q member 2
Database Link	Entrez Gene 3785 Human UniProt ID O43526
Background	Swiss-Prot Acc.O43526/O43525/P56696/Q9NR82.The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Synonyms	BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KV7.2; KVEBN1
Reference Data

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