SH2D1A Rabbit Monoclonal Antibody [Clone ID: R09-5F6]

Specifications

Product Data
Clone Name	R09-5F6
Applications	WB
Recommend Dilution	WB: 1/1000-1/2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human SH2D1A/SAP
Isotype	IgG
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 14 kDa; Observed MW: 14 kDa
Gene Name	SH2 domain containing 1A
Database Link	Entrez Gene 4068 Human UniProt ID O60880
Background	Swiss-Prot Acc.O60880.Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells . May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Synonyms	DSHP; EBVS; FLJ18687; FLJ92177; IMD5; LYP; MTCP1; SAP; XLP; XLPD
Reference Data

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