CD33 Mouse Monoclonal Antibody [Clone ID: hP67.6 (Gemtuzumab)]

Specifications

Product Data
Clone Name	hP67.6 (Gemtuzumab)
Applications	FC, IF
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Gemtuzumab was generated by huminization of the murine P67.6 clone, raised against CD33-transfected FMY9S5 cells of human origin. CD33 is a transmembrane receptor expressed on predominantly on cells of the myeloid lineage, but it can also be found on some lymphoid cells.
Specificity	Recognises human CD33. A human IgG4 variant conjugated to derivative of the cytotoxic drug calicheamicin gamma 1, N-acetylcalicheamicin dimethyl hydrazide, has been used as a therapeutic against acute myeloid leukemia. This antibody may also be used in flow cytometry and immunofluorescence.
Isotype	IgG1, kappa
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	CD33 molecule
Database Link	Entrez Gene 945 Human UniProt ID P20138
Synonyms	FLJ00391; gp67; p67; SIGLEC-3; SIGLEC3
Note	This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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