CD28 Mouse Monoclonal Antibody [Clone ID: 1C6]

Specifications

Product Data
Clone Name	1C6
Applications	Bl, ELISA, FC
Reactivity	Dog
Host	Mouse
Clonality	Monoclonal
Immunogen	Canine CD28.
Specificity	The antibody binds specifically to canine CD28, a self self surface receptor expressed by thymocytes and a subset of natural killer cells. CD28 acts as a receptor for CD80 and CD86, providing a costimulatory signal for the activation of T-cells and the production of interleukins, such as IL-6. The 1C6 monoclonal antibody has antagonistic activity, blocking mixed lymphocyte reactions and cytotoxic T lymphocyte mediated killing. The use of the monoclonal antibody 1C6 for the neutralisation of CD26 signal following T-cell receptor activation is of clinical importance for transplantation therapy, as it has been shown to prevent graft rejection and graft-versus-host disease in the canine model of allogeneic hematopoietic cell transplantation (HCT).
Isotype	IgG1, kappa
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Database Link	Entrez Gene 403646 Dog UniProt ID Q9N0N8
Synonyms	MGC138290; Tp44
Reference Data

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