ITSN1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant Human Intersectin-1 protein (773-916AA)
Isotype	IgG
Formulation	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Concentration	lot specific
Purification	>95%, Protein G purified
Conjugation	Unconjugated
Storage Condition	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Database Link	UniProt ID Q15811
Background	Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.
Reference Data

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