SF3B4 Mouse Monoclonal Antibody [Clone ID: 3A1]

Specifications

Product Data
Clone Name	3A1
Applications	ICC, IHC, WB
Recommend Dilution	WB: 1:2000 ICC: 1:1000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant full length human SAP49 expressed in and purified from E. Coli.
Specificity	Specific for endogenous levels of the ~49 kDa SAP49 protein.
Isotype	IgG2b
Formulation	PBS + 50% glycerol and 5 mm NaN3
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Predicted Protein Size	49
Gene Name	splicing factor 3b subunit 4
Database Link	Entrez Gene 10262 Human UniProt ID Q15427
Background	The spliceosome associated protein of ~49 kDa (SAP49), also known as SF3B4, is a widely expressed nuclear splicing factor that has been shown to have RNA binding activity as well as direct interaction with SAP145 (Champion-Arnaud and Reed 1994). The SAP145-SAP49 complex has recently been implicated in cell cycle progression as Vpr (viral protein 1 of HIV-1) has been shown to bind SAP145 thus interfering with the proper formation and functioning of the SAP145-SAP49 complex (Terada and Yasuda 2006).
Synonyms	MGC10828; SAP49; SF3b49; SF3b50
Note	Protein G purified culture supernatant.
Reference Data

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