Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:2000~1:5000
Reactivity	Human, Rat, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human SGK.
Specificity	SGK (S422) polyclonal antibody detects endogenous levels of SGK protein.
Isotype	IgG
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 58 kDa
Database Link	UniProt ID O00141/Q9HBY8/Q96BR1
Background	Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt. SGK is rapidly induced in response to a variety of stimuli, including serum, glucocorticoid, follicle stimulating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways. Induction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulation. SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK is negatively regulated by ubiquitination and proteasome degradation.
Synonyms	CISK; Cytokine-independent survival kinase; Serine/threonine-protein kinase Sgk1; Serine/threonine-protein kinase Sgk2Serum/glucocorticoid-regulated kinase 2; Serine/threonine-protein kinase Sgk3; Serum/glucocorticoid-regulated kinase-like; Serum/glucocorticoid-regulated kinase 1; Serum/glucocorticoid-regulated kinase 3; SGK; SGK1; SGK2; SGK3; SGKL
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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