COTL1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB:1:500~1:1000 IHC:1:50~1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant full length Human COTL1.
Specificity	COTL1 polyclonal antibody detects endogenous levels of COTL1 protein.
Isotype	IgG
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 16 kDa
Gene Name	coactosin like F-actin binding protein 1
Database Link	Entrez Gene 23406 Human UniProt ID Q14019
Background	COTL1 (coactosin-like 1), also known as CLP, is a 142 amino acid cytoplasmic and cytoskeletal protein that belongs to the actin-binding proteins ADF family and coactosin subfamily. Widely expressed, COTL1 was first identified in slime mold and is found at highest levels in kidney, placenta, lung and peripheral blood leukocytes, with low levels found in pancreas, liver and brain. COTL1 is one of many proteins that participate in regulation of Actin’s cytoskeleton through a calcium dependent mechanism, but has not been shown to have a direct effect on Actin depolymerization. COTL1 contains one ADF-H domain and interacts with 5-LO (5-lipoxygenase), an enzyme that plays a role in the biosynthesis of leukotriene and is expressed in multiple types of leukocytes.
Synonyms	CLP; Coactosin-like protein; COTL1
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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