TAF15 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000 IHC: 1:50~1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 347-398 of Human TAF II p68.
Specificity	TAF II p68 (N380) polyclonal antibody detects endogenous levels of TAF II protein.
Isotype	IgG
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 68 kDa
Gene Name	TATA-box binding protein associated factor 15
Database Link	Entrez Gene 8148 Human UniProt ID Q92804
Background	TAF II p68, also known as TAF15, RBP56 or TAF2N, is a member of the RNA polymerase II multiprotein complex and is present in certain TFIID subcomplexes. Expressed throughout the body, TAF II p68 is a single stranded RNA binding protein that shares homology with TLS (translocated in liposarcoma) and EWS (Ewing's sarcoma), both of which are proto-oncogenes. Fusion of TAF II p68 with certain transcription factors transforms it into an oncoprotein with oncogenic potential at the N-terminus. When, for example, TAF II p68 is fused with TEC (translocated in extraskeletal chondrosarcoma), the fusion pair acts as an oncoprotein in which TAF II p68 is the transactivation domain. Defects in the gene encoding TAF II p68 are associated with extraskeletal myxoid chondrosarcoma, a malignant soft tumor.
Synonyms	68 kDa TATA-binding protein-associated factor; RBP56; RNA-binding protein 56; TAF(II)68; TAF2N; TAF15; TAFII68; TATA-binding protein-associated factor 2N
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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