PRP19 (PRPF19) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding Human PRPF19.
Specificity	PRPF19 polyclonal antibody detects endogenous levels of PRPF19 protein.
Isotype	IgG
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 55 kDa
Gene Name	pre-mRNA processing factor 19
Database Link	Entrez Gene 27339 Human UniProt ID Q9UMS4
Background	The spliceosome, the 0gigantic molecular machine that performs pre-mRNA splicing in eukaryotes, contains over 200 different proteins and five RNA molecules (U1, U2, U4, U5 and U6). Pre-mRNA splicing is essential to remove internal non-coding regions of pre-mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The PRP19-associated complex is required for stable association of U5 and U6 with the spliceosome after U4 is released. Changes within the spliceosome upon binding of the PRP19-associated complex include remodeling of the U6/5‘ splice site interaction and destabilization of Lsm proteins to allow further interaction of U6 with the intron sequence.
Synonyms	hPso4; NMP200; Nuclear matrix protein 200; Pre-mRNA-processing factor 19; PRP19; PRP19/PSO4 homolog; PRPF19I; RING-type E3 ubiquitin transferase PRP19; Senescence evasion factor; SNEV
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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