Estrogen Receptor beta (ESR2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from human ERβaround the phosphorylation site of S105.
Specificity	ERβ (phospho-S105) polyclonal antibody detects endogenous levels of Erβprotein around the phosphorylation site of S105.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 48, 60 kDa
Gene Name	estrogen receptor 2
Database Link	Entrez Gene 2100 Human UniProt ID Q92731
Background	Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.
Synonyms	ER-beta; ER-β; ESR2; ESTRB; Estrogen receptor beta; NR3A2; Nuclear receptor subfamily 3 group A member 2
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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