SSB Mouse Monoclonal Antibody [Clone ID: OTI2C8]

Specifications

Product Data
Clone Name	OTI2C8
Applications	IF, IHC, IP, Simple Western, WB
Recommend Dilution	WB 1:1000~2000, IHC 1:150, IF 1:100, IP 2ug/500ul; Simple Western 1:20-1:50
Reactivity	Human, Dog, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length protein expressed in 293T cell transfected with human SSB expression vector
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.8 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	46.8 kDa
Gene Name	small RNA binding exonuclease protection factor La
Database Link	NP_003133 Entrez Gene 478787 DogEntrez Gene 710344 MonkeyEntrez Gene 6741 Human UniProt ID P05455
Background	La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006 [PubMed 16387655]).
Synonyms	La; La/SSB; LARP3
Reference Data
Protein Families	Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Systemic lupus erythematosus

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