LAT2 (SLC7A8) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI8B12]

Specifications

Product Data
Clone Name	OTI8B12
Applications	IHC, WB
Recommend Dilution	WB 1:500 IHC 1:50 Flow 1:500
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length protein expressed in 293T cell transfected with human SLC7A8 expression vector
Isotype	IgG1
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	58.4 kDa
Gene Name	solute carrier family 7 member 8
Database Link	NP_036376 Entrez Gene 50934 MouseEntrez Gene 84551 RatEntrez Gene 23428 Human UniProt ID Q9UHI5
Background	Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine orD,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney
Synonyms	LAT2; LPI-PC1
Reference Data
Protein Families	Druggable Genome, Transmembrane

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