Isocitrate dehydrogenase (IDH1) Mouse Monoclonal Antibody [Clone ID: OTI2H9]
CAT＃: TA500610
Anti-IDH1 (Isocitrate Dehydrogenase 1) mouse monoclonal antibody, clone OTI2H9 (formerly 2H9)
Formulation: Carrier-Free
Conjugation: Biotin DyLight488 HRP
View other "OTI2H9" antibodies (7)
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CNY 1999.00
CNY 2700.00
| Cited in 3 publications. |
CNY 3080.00
CNY 300.00
CNY 1430.00
CNY 2900.00
CNY 6650.00
CNY 9998.00
Specifications
| Product Data | |
| Clone Name | OTI2H9 |
| Applications | IF, Simple Western, WB |
| Recommend Dilution | WB 1:2000, IHC 1:50, IF 1:100, Simple Western 1:20 - 1:50 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Immunogen | Full-length protein expressed in 293T cell transfected with human IDH1 expression vector |
| Isotype | IgG1 |
| Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 46.7 kDa |
| Gene Name | isocitrate dehydrogenase (NADP(+)) 1 |
| Database Link | |
| Background | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. |
| Synonyms | HEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; PICD |
| Reference Data | |
| Protein Pathways | Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways |
Citations (3)
| The use of this Antibodies has been cited in the following citations: |
|---|
|
A High-Throughput Fluorimetric Assay for 2-hydroxyglutarate Identifies Zaprinast as a Glutaminase Inhibitor
,Elhammali, A;Ippolito, JE;Collins, L;Crowley, J;Marasa, J;Piwnica-Worms, D;,
Cancer Discov . April 2014
,PubMed ID 24740997
[IDH1]
[Human; WB] |
|
HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer
,null,
RNA Biology
,PubMed ID 23807417
[IDH1]
|
|
A histopathological diagnostic marker for human spinal astrocytoma: expression of glial fibrillary acidic protein-δ.
,null,
Journal of neuro-oncology
,PubMed ID 22318658
[IDH1]
|
Documents
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| CF500610 | Carrier-free (BSA/glycerol-free) IDH1 mouse monoclonal antibody, clone OTI2H9 (formerly 2H9) |
CNY 3999.00 |
|
| TA400008 | Anti-IDH1 mouse mAb, clone OTI2H9, Biotinylated |
CNY 3790.00 |
|
| TA400009 | Anti-IDH1 mouse mAb, clone OTI2H9, HRP conjugated |
CNY 3790.00 |
|
| TA400028 | Anti-IDH1 mouse mAb, clone OTI2H9, DyLight488 conjugated |
CNY 3790.00 |
|
| TA500610S | Anti-IDH1 (Isocitrate Dehydrogenase 1) mouse monoclonal antibody, clone OTI2H9 (formerly 2H9) |
CNY 800.00 |
|
| TA600198 | IDH1 mouse monoclonal capture antibody, validated for ELISA and Luminex assays |
CNY 2600.00 |
|
| TA700198 | IDH1 biotinylated mouse monoclonal detection antibody, validated for ELISA and Luminex assays |
CNY 2700.00 |
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