Munc 13 4 (UNC13D) Mouse Monoclonal Antibody [Clone ID: OTI1F4]

Specifications

Product Data
Clone Name	OTI1F4
Applications	WB
Recommend Dilution	WB 1:200~1000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human UNC13D(NP_954712) produced in HEK293T cell.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	123.1 kDa
Gene Name	unc-13 homolog D
Database Link	NP_954712 Entrez Gene 70450 MouseEntrez Gene 192177 RatEntrez Gene 201294 Human UniProt ID Q70J99
Background	This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]
Synonyms	FHL3; HLH3; HPLH3; Munc13-4
Reference Data

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