Tyrosinase (TYR) Mouse Monoclonal Antibody [Clone ID: OTI1F3]

Specifications

Product Data
Clone Name	OTI1F3
Applications	IHC
Recommend Dilution	IHC 1:150
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 19-320 of human TYR (NP_000363) produced in E.coli.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	58.3 kDa
Gene Name	tyrosinase
Database Link	NP_000363 Entrez Gene 22173 MouseEntrez Gene 308800 RatEntrez Gene 7299 Human UniProt ID P14679
Background	The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
Synonyms	ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
Reference Data
Protein Families	Transmembrane
Protein Pathways	Melanogenesis, Metabolic pathways, Riboflavin metabolism, Tyrosine metabolism

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