p95 NBS1 (NBN) Mouse Monoclonal Antibody [Clone ID: OTI2F5]

Specifications

Product Data
Clone Name	OTI2F5
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli.
Isotype	IgG2b
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	84.8 kDa
Gene Name	nibrin
Database Link	NP_002476 Entrez Gene 4683 Human UniProt ID O60934
Background	Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]
Synonyms	AT-V1; AT-V2; ATV; NBS; NBS1; P95
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Homologous recombination

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