Neuraminidase (NEU1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3D4]

Specifications

Product Data
Clone Name	OTI3D4
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 48-315 of human NEU1 (NP_000425)produced in E.coli.
Isotype	IgG2a
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	40.2 kDa
Gene Name	neuraminidase 1 (lysosomal sialidase)
Database Link	NP_000425 Entrez Gene 4758 Human UniProt ID Q99519
Background	The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008]
Synonyms	NANH; NEU; SIAL1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Lysosome, Other glycan degradation, Sphingolipid metabolism

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