DOT1L Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI6E7]

Specifications

Product Data
Clone Name	OTI6E7
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 1008-1424 of human DOT1L (NP_115871) produced in E.coli.
Isotype	IgG2b
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	164.7 kDa
Gene Name	DOT1 like histone lysine methyltransferase
Database Link	NP_115871 Entrez Gene 84444 Human UniProt ID Q8TEK3
Background	The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
Synonyms	DOT1; KMT4
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Lysine degradation

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