PHGDH Mouse Monoclonal Antibody [Clone ID: OTI5C4]

Specifications

Product Data
Clone Name	OTI5C4
Applications	IHC, Simple Western, WB
Recommend Dilution	WB 1:2000, IHC 1:150 ; Simple Western 1:20-1:50
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human PHGDH (NP_006614) produced in HEK293T cell.
Isotype	IgG2a
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	phosphoglycerate dehydrogenase
Database Link	NP_006614 Entrez Gene 58835 RatEntrez Gene 236539 MouseEntrez Gene 26227 Human UniProt ID O43175
Background	This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
Synonyms	3-PGDH; 3PGDH; HEL-S-113; NLS; NLS1; PDG; PGAD; PGD; PGDH; PHGDHD; SERA
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Glycine, serine and threonine metabolism, Metabolic pathways

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