TIM 3 (HAVCR2) Mouse Monoclonal Antibody [Clone ID: OTI2E2]

Specifications

Product Data
Clone Name	OTI2E2
Applications	WB
Recommend Dilution	IHC 1:150
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 22-202 of human HAVCR2(NP_116171) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	33.2 kDa
Gene Name	hepatitis A virus cellular receptor 2
Database Link	NP_116171 Entrez Gene 84868 Human UniProt ID Q8TDQ0
Background	The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
Synonyms	CD366; HAVcr-2; KIM-3; Tim-3; TIM3; TIMD-3; TIMD3
Reference Data
Protein Families	Druggable Genome, Transmembrane

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