Jagged1 (JAG1) Mouse Monoclonal Antibody [Clone ID: OTI3A10]

Specifications

Product Data
Clone Name	OTI3A10
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 523-759 of human JAG1(NP_000205) produced in E.coli.
Isotype	IgG2a
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	133.6 kDa
Gene Name	jagged 1
Database Link	NP_000205 Entrez Gene 16449 MouseEntrez Gene 29146 RatEntrez Gene 182 Human UniProt ID P78504
Background	The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
Synonyms	AGS; AHD; AWS; CD339; HJ1; JAGL1
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Notch signaling pathway

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