JIP1 (MAPK8IP1) Mouse Monoclonal Antibody [Clone ID: OTI3A12]

Specifications

Product Data
Clone Name	OTI3A12
Applications	WB
Recommend Dilution	WB 1:2000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human MAPK8IP1 (NP_005447) produced in HEK293T cell.
Isotype	IgG2b
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	77.3 kDa
Gene Name	mitogen-activated protein kinase 8 interacting protein 1
Database Link	NP_005447 Entrez Gene 19099 MouseEntrez Gene 116457 RatEntrez Gene 9479 Human UniProt ID Q9UQF2
Background	This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
Synonyms	IB1; JIP-1; JIP1; PRKM8IP
Reference Data
Protein Families	Druggable Genome
Protein Pathways	MAPK signaling pathway

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