Ube1L (UBA7) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2B6]

Specifications

Product Data
Clone Name	OTI2B6
Applications	IHC, WB
Recommend Dilution	WB 1:500~2000, IHC 1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human UBA7 (NP_003326) produced in HEK293T cell.
Isotype	IgG2b
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	111.5 kDa
Gene Name	ubiquitin like modifier activating enzyme 7
Database Link	NP_003326 Entrez Gene 7318 Human UniProt ID P41226
Background	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]
Synonyms	D8; UBA1B; UBE1L; UBE2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Parkinson's disease, Ubiquitin mediated proteolysis

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