beta Arrestin 1 (ARRB1) Mouse Monoclonal Antibody [Clone ID: OTI2B3]

Specifications

Product Data
Clone Name	OTI2B3
Applications	WB
Recommend Dilution	WB 1:500-2000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human ARRB1 (NP_004032) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws.
Predicted Protein Size	47.1 kDa
Gene Name	arrestin beta 1
Database Link	NP_004032 Entrez Gene 25387 RatEntrez Gene 109689 MouseEntrez Gene 408 Human UniProt ID P49407
Background	Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011].
Synonyms	ARB1; ARR1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Chemokine signaling pathway, Endocytosis, MAPK signaling pathway

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