XPC Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~2000
Reactivity	Human, Rat, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human XPC
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	2.55 mg/ml
Purification	Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	105.8 kDa
Gene Name	XPC complex subunit, DNA damage recognition and repair factor
Database Link	NP_004619 Entrez Gene 22591 MouseEntrez Gene 312560 RatEntrez Gene 7508 Human UniProt ID Q01831
Background	This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Synonyms	p125; RAD4; XP3; XPCC
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Nucleotide excision repair

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