PREX2 (NM_025170) Human 3' UTR Clone

CAT#: SC200076

3' UTR clone of phosphatidylinositol-345-trisphosphate-dependent Rac exchange factor 2 (PREX2) transcript variant 2 for miRNA target validation



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CNY 4845.00


货期*
3周

规格
    • 10 ug

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Specifications

Product Data
Product Name PREX2 (NM_025170) Human 3' UTR Clone
Vector pMirTarget
Synonyms DEP.2; DEPDC2; P-REX2; PPP1R129
ACCN NM_025170
Insert Size 677 bp
Sequence Data
>SC200076 3’UTR clone of NM_025170
The sequence shown below is from the reference sequence of NM_025170. The complete sequence of this clone may contain minor differences, such as SNPs.
Blue=Stop Codon Red=Cloning site

GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG
TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC
ATGCTCTTAGCAGAGAGGGCCCCTGTCTGATTCTTACCCTTTGGAACAGTTCAGGCACCCTTAGACACA
GTACACAGCCCTTCCTAGCATGTGGGCAGGGGGACATCCTGTATTCACAGGCATTTGTATTGAGCTACA
AGTTGGAAAGCCAGTCCCCCTAGCAAGAGAATCTTCTGCCAGCTCTCCCCGATTACTCCATTAACACTT
CTTGACATCACCCTATTCATTTCCTTTTCAGCTTGTACCAAAATTTCTAACTATCTGGCTTTTACGTGC
ATTATATAATTGTATATATACAGTCATGCACTGCATAACATTTCAGTAAATGACAGACCATATATATAT
GGATTATATATATATATATATATGGATATATATACACATATATATACACACACATATATATATATATAC
ATATATATGTATATATATATAAAATGGTGGTCCCATAAGATTATACTACTACATTTTGGCTCTACTTTT
TCTATGTTCAGATAGATGCACCTATTGGTGTATTTTTCAGAATACATCCCCGTTGTTAAGCAATGCATT
ACTGTATTATATATATGGCACATGTATTATATATATGGCACATTGCCGTTACTTTTAATGGCAAAAACC
GCAATCACTTTTGCTCCAACCTAGTAATTGCAATAAACAATTGTTGTATATAGCAA
ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA
CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites SgfI-MluI     
OTI Disclaimer Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq NM_025170.6
Synonyms DEP.2; DEPDC2; P-REX2; PPP1R129
Summary The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016]
Locus ID 80243
MW 26.4
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