Cardiac Troponin I (TNNI3) (NM_000363) Human 3' UTR Clone

Specifications

Product Data
Product Name	Cardiac Troponin I (TNNI3) (NM_000363) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1
ACCN	NM_000363
Insert Size	97 bp
Sequence Data	Insert Sequence (showhide) >SC200472 3’UTR clone of NM_000363 The sequence shown below is from the reference sequence of NM_000363. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAGGGCCGCAAGAAAAAGTTTGAGAGCTGAGCCTTCCTGCCTACTGCCCCTGCCCTGAGGAGGGCCCTG AGGAATAAAGCTTCTCTCTGAGCTGAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000363.5
Synonyms	CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1
Summary	Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020]
Locus ID	7137
MW	3.6

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