C4orf27 (HPF1) (NM_017867) Human 3' UTR Clone

Specifications

Product Data
Product Name	C4orf27 (HPF1) (NM_017867) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	C4orf27
ACCN	NM_017867
Insert Size	138 bp
Sequence Data	Insert Sequence (showhide) >SC201015 3’UTR clone of NM_017867 The sequence shown below is from the reference sequence of NM_017867. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAAGAGAACATAGACCAACTTGCTGCATGAGTAAGGTGGCTTTGATTGGTGTACAGTATTTCAAAGGAC TAGTATTAAACTTGTGATTTTTGTTTTGTTTTTAAGGAATACAAAAAATAAACATTTACTAAAAACGTT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_017867.3
Synonyms	C4orf27
Summary	Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine (PubMed:28190768, PubMed:29480802). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1 (PubMed:30257210).[UniProtKB/Swiss-Prot Function]
Locus ID	54969
MW	5.6

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