WIBG (PYM1) (NM_001143853) Human 3' UTR Clone

Specifications

Product Data
Product Name	WIBG (PYM1) (NM_001143853) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	PYM; WIBG
ACCN	NM_001143853
Insert Size	507 bp
Sequence Data	Insert Sequence (showhide) >SC206452 3’UTR clone of NM_001143853 The sequence shown below is from the reference sequence of NM_001143853. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAGTTAGAGGACTTGGAGTTAGGCCTCTGAGGCCTTTGGGGAATAGGGAATGGACTGCAGAACAAACCG TGGGGCTCTCTGGGGTCTGGGGGAATACGGGCAACAGCAGTCAGGAGGGGTACCCCCCATACTGGCTTA CTTCCACCTCCTGCGGCCCAGCTCTGTCCTCCAGAGCCTAGCGTCTCCCTCAATCCTTCCCTTTTCTTC CCAACTTCTACTTTTTGGACTTTCCCCCTCCCATTCCCAGTGTTCAAAATCTCAGTGACTACCCCAGGT ACCTTTGCTGCTGATTTGGGTGTCTTGTTTAAAAGAAAATCAGGTGGGTGGGAATCTCTTGGAGAACTG AGGCTGAGGGTAGAGGGAGTATGCCCAAGTCTTGGAGTCTTGGTTCCTGTTCGCGGTGTTTATGGGTTA TTTCCCTCTCCATCCCTCATTTTTTTTTTTTTTTTAAAAAAAGCAAAAATGAGAATAAACACAAGTAGA CATGTCAAAAAAAAAAAAAAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001143853.1
Synonyms	PYM; WIBG
Summary	Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.[UniProtKB/Swiss-Prot Function]
Locus ID	84305
MW	18.4

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