SELS (SELENOS) (NM_018445) Human 3' UTR Clone

Specifications

Product Data
Product Name	SELS (SELENOS) (NM_018445) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP
ACCN	NM_018445
Insert Size	610 bp
Sequence Data	Insert Sequence (showhide) >SC207957 3’UTR clone of NM_018445 The sequence shown below is from the reference sequence of NM_018445. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AGAGGCCCGTCATCTGGCGGATGAGGCTAAGAATCTTGTTAGTGTCACTTTTGACATTAGCAAGATGAA CCCTTAACCCTCGATTCAATTGCCTTACGCACGCTTTTCACAGTGACTAGCCAAGGGGAGGTGGGGTTG ATTTCTGTTCCTAACTACACCTGCATATGTCAGGGCTCCAGTCAGCAAAAGGTATAGATGTTGCCTCTA GGCATGAGGTCATTGGTCACATTCTACTTGGAGACAGTGATTGCATTCATTGATTTCATGGTTAATTGC TAGTTGGTAGGTAAAGGCCTCTAGATGATTAGCAATCTTGATAAAAGAGGCCTAGTAATGTTCTTTTGA GGTTAGAAATCCTTGCTGCTAGGACAGTCTCTGTGACAGGTTGCGTTGAATGATGTCTTCCTTATCAAT GGTGAGCCCACCAGTGAGGATTACTGATGTGGACAGTTGATGGGGTTTGTTTCTGTATATTTATTTTTA TGTACAGAACTTTGTAAAAACGAAACTATTTAAAAAACAAGAATAACATTTTTAGCATCTTTATTCAAG GAGATTTATGGACTTCAATTTGTCTATCAAACATTAAATAGCTTTTTATTACAACCTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_018445.6
Synonyms	AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP
Summary	This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
Locus ID	55829
MW	22.6

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