MHF2 (CENPX) (NM_144998) Human 3' UTR Clone

Specifications

Product Data
Product Name	MHF2 (CENPX) (NM_144998) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CENP-X; D9; FAAP10; MHF2; STRA13
ACCN	NM_144998
Insert Size	532 bp
Sequence Data	Insert Sequence (showhide) >SC208323 3’UTR clone of NM_144998 The sequence shown below is from the reference sequence of NM_144998. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTGCTTCCGCAGCTGCTCCTGGACTTCTAGGGATCTCAGCCGTGGCTGAGGCCACCCCCAGAGGAGCCC CTGGTCCACAGAAGCAGGCCTTGTGTTTCCAGCGGCCTCTGATAAGAGGCAGGGAAGGACCTGAAGGAT TTGGAGTTGATTCAAACAAGATCTCTGGGAGTCTCCAGCCTGTGCAGAAGGGGCAGGACTGCAGTGCAC TGCGGGCCTTGGAGTGTCCAGTGGGGACACTGGTGTGGGAAGGGGCAGCACCTGGGGAGTCCCTGCCTC TCCTCCCTGGGACAATAGTGTGCATGCCACCCGGGGTCCTACAGGCAGGTGCTGGGAAAGGCCTGGCCA GCAGGTAGCCTGTGTGTTTGACAAACAGCAGCTGGCAGCGCTGCCTCCTGCCCACATTCCTGCCACCCG ACATCAAAGCTGGCGTGTGACCTTTCCAGCCATGCGATATTCCCCTTGGAAGATGCTTCCCCAGGCTAT AAATTTGTTCTCACAAAGCAACATCAATAAATCAAAACTGTCTCTCCCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_144998.4
Synonyms	CENP-X; D9; FAAP10; MHF2; STRA13
Summary	DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:20347429). DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347429).[UniProtKB/Swiss-Prot Function]
Locus ID	201254
MW	19

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