JIP1 (MAPK8IP1) (NM_005456) Human 3' UTR Clone

Specifications

Product Data
Product Name	JIP1 (MAPK8IP1) (NM_005456) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	IB1; JIP-1; JIP1; PRKM8IP
ACCN	NM_005456
Insert Size	774 bp
Sequence Data	Insert Sequence (showhide) >SC209745 3’UTR clone of NM_005456 The sequence shown below is from the reference sequence of NM_005456. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TGCCCCACAGAAGATATCTACCTGGAGTAGCTGTGCAGCCCCGCCCTCTGCGTCCCCCAGCCCTCAGGC CAGTGCCAGGACAGCTGGCTGCTGACAGGATGTGGCACTGCTTGAGGAGGGGCACCTGCCACCGCCAGA GGACAAGGAAGTGGGGGCCGCTGGCCCAGGGTAGGGGAGGGTGGGGCAATGGGGAGAGGCAAATGCAGT TTATTGTAATATATGGGATTAGATTCATCTATGGAGGGCAGAGTGGGCTGCCTGGGGATTGGGAGGGAC AGGGCTTGGGGAGCAGGTCTCTGGCAGAGAAGGATGTCCGTTCCAGGAGCACACGGCCCTGCCCCATCC TGGGCCTTACCTCCCCTGCCAGGGCTCGGGCGCTGTGGCTCCTGCCTTGATGAAGCCCGTGTCCTGCCT TGATGAAGCCTGTGCCACCTGCAAGTGCCCGCCCTGCCCCTGCCCCAACCCCCACCGAAGAGCCCTGAG CTCAGGCTGAGCCCAGCCACCTCCCAAGGACTTTCCAGTGAGGAAATGGCAACACGTGGAGGTGAAGTC CCTGTTCTCAGCTCCGTCATCTGCGGGGCTTCTGGGTGGCTCCTGCCACTGACCTCACCGGCATGCTGG CCTGTGGCAGGCCTAGGACCTCAGGCGGGGAGGAGGAGCTGCCGCAAGGCCCTGTCCCAGCAGAAGAGG GAGGCTTCCTGACTGACACAGGCCAGCCCCATCTTGGTCCTGTCACCCTGGCCCCAACTATTAAAGTGC CATTTCCTGTCTGGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005456.4
Synonyms	IB1; JIP-1; JIP1; PRKM8IP
Summary	This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
Locus ID	9479
MW	26.9

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