NYREN18 (NUB1) (NM_016118) Human 3' UTR Clone

Specifications

Product Data
Product Name	NYREN18 (NUB1) (NM_016118) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	BS4; NUB1L; NYREN18
ACCN	NM_016118
Insert Size	1254 bp
Sequence Data	Insert Sequence (showhide) >SC213354 3’UTR clone of NM_016118 The sequence shown below is from the reference sequence of NM_016118. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AATAGGAAGTCAGCAACAAAGAAAAACTAAATAATGAACAGAAATAGCGCTAATTTTCTGCTTATAAAT GCTATCATTATGAAAAGGCTAATGCAGCTCTTTCTGTTCTTACTTTTTATCTGAATTACAAGTCCTCTT TGGGTGTAGGAGGGGGTGGGCAGGGGACAAGTCCAGGAGGGGTCCCAGGGCCTTCATGCGTGGTCTCGG GGAAGAAGCTTCCTCTGGCCTGGCGCAGGCCGTTCCATCTGCCTCCCAGGTCTGCGTCCCTAACCCCTT CCCCAGCTTGGTGTTTTACCCCGAAACAGGAAGGAACAGGGGTCCTGTAGAACAGGGGTCCTGGGGAAG GTGTCCAGGGCAGGGTCCTGGGAAGGGTGTCCCGACCGCTTCCTCTCCAGCTGTGGCTCCATCTGCCCA GCTTGCCTGCCTCCTGCACCCACTGCCCTGACCTTCCTGCTTCCCACGCTGCCATCTCTGCCAGGGTGC CACATGGGTTCCTGTGCCACCCTTTCCCCGCCCCTCAAATCGTCCTTTAAGTCTTCCTTCCAAGTGCTG TGGGGCATAACGATGAGGCGCTGGCCTTGGGGGCCACACCAGGTCGCAGCAAATGGCTTCAGCCTGGGA CGCCAGTGTTTTATGCTCTTAGTTCAGTAAAATACGCCCCCGAAATTCAAGATTGAGTGTCAGGCTTTA TATATATTCAGCATTCCTCATTACAGAAATCTTCTATTGAATGGGAAAGGTTTAAATGCTAACCAAAGC AATTTATTTTTAATTAATATTTTTAGACTCTGTGCTGTCATACTGAACTCACTGCTAGCTAAGAGACCT ATCAGAGATTTAGATATATTTTCTCCAGGTTTTTTGTGGGTTTTCTTTGTTGTTGTTGTTGTTCTAGCC ATGTGACAGAGGCTCTTTCTAAAAGTATGTAGTTCGCTGTGTGTCGGCTCCAGCAGTAACCGTCCTCAC TGCGCCACGCACTCCTCTGTAGATGTGTGCCCAGTGGGAGTTCCTTCCAGCCCCAGGACCACAGCAGCA GCCAGGTGCCGAGTGGATTGAGTGCCAGGTGCATCCAAGACTTTCCCTCCCTTCCAGAAGGCACTGACT GAAGACAGGATGGATCATGCGGAGCCGGCTGAAATGCTCCAACTTTTTCAAAGTGTGGGTGGTCCAGTT TGGACTGATGGGAATCTTCTTGTCATTCTTTTTAAACGGATGATACCGATGGAAATAAAAGGTGGGAAA TATATTCAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_016118.5
Synonyms	BS4; NUB1L; NYREN18
Summary	This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Locus ID	51667
MW	46.1

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