TTLL12 (NM_015140) Human 3' UTR Clone

Specifications

Product Data
Product Name	TTLL12 (NM_015140) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	dJ526I14.2
ACCN	NM_015140
Insert Size	1416 bp
Sequence Data	Insert Sequence (showhide) >SC214300 3’UTR clone of NM_015140 The sequence shown below is from the reference sequence of NM_015140. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGTGGCTGCCACGTTACCTGCCTTGTCTAGGCACTCGCTGTCCCCAAAACCTGTGCTTGGGGCAGGATT CCAACCTCAGTTCTCTGAGCTGCTTCTGCAAAGGCCCCCATGTCCCTCCCCACACCGGCCCTGGGCATA GCCTCAGCCCCAGGCCTCTGTCCTGCCGAGCCATCCTCCCGGCGCCACACTCCGGGAGCACAGCATCCT CCTCTCACCTGTGGGTCAGAGCAGGACAGTGATGGTGTCCCCAGGGCTGAGCACCACCCCACGCCCTGC CCTCACCCCTCACCACCATCTGTGCACTGATGAGTCTCCAGTTTAGCCAAGGGCTTTGTTCCTGGCATG GAGAATTTGTTCCTGGCTGCTGTGTTTCCAGGGGGTGCTGGGGGAAGGGTTCCGTGGAGCGAGACAAGG TGTCCTCGGGAGCAGGGTTCCACCGGGAAGCGTTTGGGAGCCCTGTATCACACGGGGCAGGCGGGTTTC TCTTCCGGGGTCTCTGCTCTTATGCATCAGGACGACCCCGGGACGGCTGTGGGGCCCCACACTGCACCC ACAGGGCTCTATGCGACAGGGGCCCAGGAACAGCCTGAGGCCACCACCCAGCAAGCCCGCCTTATCACC CATTCCAGCTCACCCAGAACCTTCACCAGCAAACCTCCTGCTGAGGTCCTGGCAGGAGGCCACCGTCTT GTTACCGTTTCCTTTTCGTTTGCTGAGGGTCACAGACCCCAACAGGGAAATCAGTATCTGTCTTCCCAG TGGTTGCCCTGCTCGCCGGGCACTCCACGGGGTCCCGCCCTTGTGTGAGATGGGCCAGGATCCTTCGGC AAGGGGCGCCTGGGGCTGGGGCTGATTGTGGGCGGTGGAGCGCCAGACAGAAAAGGATTCCAATGAGAA CTTCAGGTTAAAGTCAGATGCCACCTACCAGGGTCTACAGTCAAAATGTTGGCTTTTTCTTATTTTTTA ATGTATGGGAGAAAAATGTAAAATTCCAGTTCTTTTCTAATTGTGTTTCTGAAATTAGGAGTCAGCTGC CAGCGTTTTTGTGTGGCTGCAGTGTGCCTGGGCCCAGCTCACGGGCAGTGGGTGGACCTAACTGCCCAG GCAGGCGAGAGCTACTTCCAGAGCCTTCCAGTGCATGGGAGGGCAGGGCTAGGTGTAGCGGTGTCTCCT CTTTGAAATTAAGAACTATCTTTCTTGTAGCAAAGCTGCACCTGATGATGCTGCCTCTCCTCTCTGTGT TGTCTGGGCCCTTGTTTACAAGCACGCGTTACCCTTCCTGAGGGGAGCCATGCTCTAGCCCCTGGAGGG CCTGTTGCAGGGGCAGGGCGGGCCCGTCGCCTTTGGCAGCTCCTGGAGAGCTGTGGACATGCAGTCCCC CTCAGTTCGTGCTGCAATAAAGGCCATCTTCTCTTA AGCGGACCGACTTACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCC CAACCTGCCATCACGAGATTTCGATTCCACCGCCGC
Restriction Sites	SgfI-RsrII
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_015140.4
Synonyms	dJ526I14.2
Summary	Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).[UniProtKB/Swiss-Prot Function]
Locus ID	23170
MW	49.1

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