AF9 (MLLT3) (NM_004529) Human 3' UTR Clone

Specifications

Product Data
Product Name	AF9 (MLLT3) (NM_004529) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AF9; YEATS3
ACCN	NM_004529
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC214777 3’UTR clone of NM_004529 The sequence shown below is from the reference sequence of NM_004529. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AGTTACCTGGAAACATCTGGAACATCCTGAGGATATAACAACTGGATGCATCAAGAACTATTGTGTTTT TTTTTTTTGGTTTTTTTTTTTTTTGGTTGTGATTTTTTGTTCTTGTTGTTTATATGAAAACACTCAAAA TGATGCAACCAAAAGGGAAAAAATAAAAATCAAACAACCTTCAGCTTTATTTTTCTTTAAAGCCAGTCA TCATCTCTTGATAAAGGAGAGGTTAAAGCAAACCAGCCTCAGCGGACCACTCTTCTCTCCAAGGAAATC CCCGGGAAGAGTTAGCCTGGATAGCCTTGAAAACAAACAAATCAAACACAACACAAGAAAACTCAAAGA ATGTGTATGGTATCATGTATCTCTCTGTGGTGGTTCATTCCACAGGACGAATGCATATTCAACACACTG CCTTATTACATAACTGATCTATTTATTATCGCATACAGATATTCTAAGTCGTTGAGGGAATGACACCAT CAGACATTATAAGTACTTGGTCCCGTGGATGCTCTTTCAATGCAGCACCCTTGCCATCCCAAGCCCAGT GACCTTACTCGTATACCGTGCCACTTTCCACCAACTTTTTCCAAGTCCTTTAACTCGTTGCAGTCTGTA TTTTCCACCTTTTGTTTTTCCAGTTCCAGGACACAGATTATCAACTGGGGGGACCAAATAGCCACCTTG ATTTTCTTCTTTGTGGTCTTTTTCCTGAAAGTTGGGGCCCAGTCCTTGGCTGTATCCATGTAATGATCT TGGACCATGGTAGAAAATGCACCAAATAGGATCATATGAATTGCTGTCTAGCCTTAGTCAATAAACTTG TAGGACTTTTAAACAAAAGTGTACCTGTAAATGTCCTGAATCCAGCATTGTTGAGCTGTCATCAACATT CTTGTGTCTGTTTTACTGTTACAATATTAGGTGAATATGGAAGTAAAGGCATTCCACAGGATCATCATT TAAAAAAAAAGAATTCTGGTCCTGTTTTCTAAAAAAAAAAACTGTTGTAGAAATTCTTAATTTGGATCT ATTTATTAGTCAGAGTTTCAGCTTTCTTCAGCTGCCAGTGTGTTACTCATCTTTATCCTAAAAATCTGG AATCAGAGATTTTTGTTTGTTCACATATGATTCTCTTAGACACTTTTATATTTGAAAAAATTAAAATCT TTCTTTGGGGAAAAATTCTTGGTTATTCTGCCATAACAGATTATGTATTAACTTGTAGATTCAGTGGTT CAATACCTGTTTAGTTGCTTGCTAATATTTCCAGAAGGATTTCTTGTATTGGTGAAAGACGGTTGGGGA TGGGGGGATTTTTTTGTTCTTGTTGTACCCTTGTTTTGAAACTAGAAATCTGTCCTGTGGCATGCAAAA GAAAGCAAATTATTTTTAAAAGAAAAAAACCAAAGTACTTTTGGTGTCATTATTCCATCTTCTCCATAA GTGGAGAAATGAAAAGTAAGAACAGCTCATCTTCAAAGTTTTTACTAGAAATTCAGCCGAAAAGAAGAG AAATGAAGAAATACTTCTGGATCCAAAGGTTCGTCACTGGATCAGCCTTAAGAAAGTCTCTATGTGTGC TAATAGACCAGTATCTCCCTTGTTTGTTCCCATGCCAGATGCTGTCTTTTCATACAGAGATTAACTAGT GTCTGTACAGAAAATGGTCTTTCCAGACCCATTCTTTTGGGCAGTTATATAAATGCAGATTGATAATGG AGTTATTTCTGCATTTTAAAAAGGGGATTTTTTACACTGTTTCTTTCTATCCAAAGAAACTATTTTTCC TTTAAAAAATTATAATACAGCCATGCTCCTTGTAAATTATTTCTCTGAAGCGTCCTCCCAGAGGACAAG TGTACTTTCTCAATAATGTTATGATTCTTAATGACGATTGGCATGAACCGTACTTGAAGCATTTGTTGT ATTGTCCACTTCTTGATGTGCAGAGAAACTTTGAGTCATTTTGGACATTAGGTGATTGATGAATTGTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_004529.4
Synonyms	AF9; YEATS3
Summary	Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619).[UniProtKB/Swiss-Prot Function]
Locus ID	4300
MW	77

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