RICH2 (ARHGAP44) (NM_014859) Human 3' UTR Clone

Specifications

Product Data
Product Name	RICH2 (ARHGAP44) (NM_014859) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	NPC-A-10; RICH2
ACCN	NM_014859
Insert Size	1502 bp
Sequence Data	Insert Sequence (showhide) >SC214865 3’UTR clone of NM_014859 The sequence shown below is from the reference sequence of NM_014859. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAGGAGGAGTCTGAGAGCACCGCCCTCTGACATGACACCGCCCATCCTGCCTCGCGTGTACATACATCA CGGGCCCTAGGAACGCCGCCAGGAGCAGCGTCCATGAGCTTGCCAAGTGTTCTCTGCTGGCTCTTTCCT GCCACTGCCAACACGAGGTTGGAATTTGGCAGAAAATTGTGATCTCCAGTCCGTGTGGTGATGCTGGTG GTGCAGGTTTTGTTTGTTCCTTTCGGGTGGTGACTTCGGCCTTTTGTTTGACCTTTGCCTTTTGACTTT GTGCCTCTTTTGATCCACTTTCAGCCTCCATGCCAGAAAACACCCACCTCTCCATCCAAGGCTGGTCAG GAACGTCCTTTGCAGGGTCGGGGTGGTGCGGGAGAGGCTCACTTTGCCTGGTTAGACCCAAGGGCTGCT ACCTTTTCCTTGGACGGCTCATGTCAGGTCTTGCAGGATCAGTTTAATGGCCACAGAAAGGAAGCAGGA CAGCAGGGCCCCTCTCACCCACAACTGGACCAGGTCCAGGATTCTAGCAGTCCTGGGGCACTGACCTTT GCCAGCTACCTGGGGGAGGGCTTGCCACTGGAAAACCTTTCAGGCCGCCCCCATCAGTGGGCTCCAAAG TAAATGGCTGAAAACAAAAATGTTTCACTTCCTAACAGTTTTCCTTTTTCCACTGTGTGACTGAAAGCT CCTATATCATTTTATATTTCTGAATCTATAAAACAAAACAAACAAGCCTGACAGTGTCTGGAGGAGCCA AAGGTGGCCTCCCTGTCCCCAAATATATTGGCTATATGAGAGTAATTTTACCCCTCTACGTACCTAAAG GCACCCAGTTCACTAGTCTGTGGGGTCCTGGAGCCTGTCTCTTCTTTCTGGAGGTTCAAACTGAATAGC AATAATTACGTTACCCAAAGCATGTGGAGGAAAAGTGAAACCAGCCACGGAGACGCTGGCCCACGGGCT CGGCCTGCGGTGTGGCCTGCTTTGCTCACCAGCGTCAGCCGCTCATTTCCTTCTCATGAAGTCCCATCT GGTCATGGGGACGAGGGCCGGGAGGGCACCGGGTAGCCTTTTCACACTTGGGGATTAGGGGAGTGAGAA AAGATTTGGGCCATGCATGCAAAGTCAAAGTTTAAAATTTTATCCTTTTCAAATAGATGATATAATATA CCTATACATGATATAATATTTGTATATATGAAATCTCTCTATATTTGTTTAATTTGAGCCATTCAATCT AAACCAATGTACAGGTGTACAATGAAAAATTTAAATGCTTAGTTATTTTTCCCAACACAGTGTAAAGTC ACCCTCCTCTGAGAGTGGGATGTGCAGAGTTTTGATGTTGCAGCTTTGCTCACTTCCTGGCAAGGGCAG GTCATGCCTCAATTTGTAATGGGAGTCTGGGGTAAGGGTGGGGGTTGAAAGTTGTTATCTTTAAATACA TGTACAAATCGTTGTCAAAAGTAACGTTATTAAAATAGATTTATTATCCCTGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_014859.6
Synonyms	NPC-A-10; RICH2
Summary	GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	9912
MW	55.6

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