MADH7 (SMAD7) (NM_005904) Human 3' UTR Clone

Specifications

Product Data
Product Name	MADH7 (SMAD7) (NM_005904) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CRCS3; MADH7; MADH8
ACCN	NM_005904
Insert Size	1549 bp
Sequence Data	Insert Sequence (showhide) >SC215141 3’UTR clone of NM_005904 The sequence shown below is from the reference sequence of NM_005904. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TGGCTAGAGGTCATCTTCAACAGCCGGTAGCCGCGTGCGGAGGGGACAGAGCGTGAGCTGAGCAGGCCA CACTTCAAACTACTTTGCTGCTAATATTTTCCTCCTGAGTGCTTGCTTTTCATGCAAACTCTTTGGTCG TTTTTTTTTTGTTTGTTGGTTGGTTTTCTTCTTCTCGTCCTCGTTTGTGTTCTGTTTTGTTTCGCTCTT TGAGAAATAGCTTATGAAAAGAATTGTTGGGGGTTTTTTTGGAAGAAGGGGCAGGTATGATCGGCAGGA CACCCTGATAGGAAGAGGGGAAGCAGAAATCCAAGCACCACCAAACACAGTGTATGAAGGGGGGCGGTC ATCATTTCACTTGTCAGGAGTGTGTGTGAGTGTGAGTGTGCGGCTGTGTGTGCACGCGTGTGCAGGAGC GGCAGATGGGGAGACAACGTGCTCTTTGTTTTGTGTCTCTTATGGATGTCCCCAGCAGAGAGGTTTGCA GTCCCAAGCGGTGTCTCTCCTGCCCCTTGGACACGCTCAGTGGGGCAGAGGCAGTACCTGGGCAAGCTG GCGGCTGGGGTCCCAGCAGCTGCCAGGAGCACGGCTCTGTCCCCAGCCTGGGAAAGCCCCTGCCCCTCC TCTCCCTCATCAAGGACACGGGCCTGTCCACAGGCTTCTGAGCAGCGAGCCTGCTAGTGGCCGAACCAG AACCAATTATTTTCATCCTTGTCTTATTCCCTTCCTGCCAGCCCCTGCCATTGTAGCGTCTTTCTTTTT TGGCCATCTGCTCCTGGATCTCCCTGAGATGGGCTTCCCAAGGGCTGCCGGGGCAGCCCCCTCACAGTA TTGCTCACCCAGTGCCCTCTCCCCTCAGCCTCTCCCCTGCCTGCCCTGGTGACATCAGGTTTTTCCCGG ACTTAGAAAACCAGCTCAGCACTGCCTGCTCCCATCCTGTGTGTTAAGCTCTGCTATTAGGCCAGCAAG CGGGGATGTCCCTGGGAGGGACATGCTTAGCAGTCCCCTTCCCTCCAAGAAGGATTTGGTCCGTCATAA CCCAAGGTACCATCCTAGGCTGACACCTAACTCTTCTTTCATTTCTTCTACAACTCATACACTCGTATG ATACTTCGACACTGTTCTTAGCTCAATGAGCATGTTTAGACTTTAACATAAGCTATTTTTCTAACTACA AAGGTTTAAATGAACAAGAGAAGCATTCTCATTGGAAATTTAGCATTGTAGTGCTTTGAGAGAGAAAGG ACTCCTGAAAAAAAACCTGAGATTTATTAAAGAAAAAAATGTATTTTATGTTATATATAAATATATTAT TACTTGTAAATATAAAGACGTTTTATAAGCATCATTATTTATGTATTGTGCAATGTGTATAAACAAGAA AAATAAAGAAAAGATGCACTTTGCTTTAATATAAATGCAAATAACAAATGCCAAATTAAAAAAGATAAA CACAAGATTGGTGTTTTTTTCTATGGGTGTTATCACCTAGCTGAATGTTTTTCTAAAGGAGTTTATGTT CCATTAAACGATTTTTAAAATGTACACTTGA AGCGGACCGACTTACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCC CAACCTGCCATCACGAGATTTCGATTCCACCGCCGC
Restriction Sites	SgfI-RsrII
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005904.4
Synonyms	CRCS3; MADH7; MADH8
Summary	The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Locus ID	4092
MW	58.1

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