MPP8 (MPHOSPH8) (NM_017520) Human 3' UTR Clone

Specifications

Product Data
Product Name	MPP8 (MPHOSPH8) (NM_017520) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	HSMPP8; mpp8; TWA3
ACCN	NM_017520
Insert Size	1596 bp
Sequence Data	Insert Sequence (showhide) >SC215523 3’UTR clone of NM_017520 The sequence shown below is from the reference sequence of NM_017520. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ATAGGTGCATACAGAGTGCAGCTGCAGTGACCAAACAGAAGGGACTGGGCGGAGTTCTCTTCAGACCGA TTCCTATACTCTCTTTGACAGCAGTTTGGAATTCTTCTAGCACATCTATGTAAAGTTTTGTCTGTAAAC CTCTTGCAGTTAAGCCTGTTGTCTGTTGTAGTCTGTAAGATGCGACATAGCTGTGTCTGTGCCAGTATG CCGGAATCTCAGTGCAGTGTCCAGACTGCGTATTTCAGTTTTTCCACAATGTGGATAGTACATATGAGG ATTATTTAAGAAAATTAAAGACTTCACTTTCTTTTTTCTGGAGACGGAGTTTCGCTCTTGTTGCCCAGG CTGGAGTGCAATGGTGCGATCTCGGCTCACTGCAAGCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCC TCAGCCTCCTGAGTAGCTGGGATTACAGACACCCGCCATGGCACCCAGCTAATTTTGTATTTTTAGTAG AGATGGGGTTTATCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCCGCCTCGG CCTCCCAAAGTGCTTGGATTACAGGCATGAGCCACCGCACCCAGCAAGAGTTATTTTCTTAACTTGAAA TTTTCTACTAGCCCTGGTGAACTTCTGTGCTTAAAAAAAAAAAAAAAAAAAGGAAAAATTCAGCTCTAA AACATTTGCTTACAGCAAGGGAGCCATGTTATATTCAAGTTACCCAAGCACCAAATAAAGTGTGGGTTT GCTGCCCTTGAAAGGGTTGGGAGGCCTGATCTTTTTCTAGTAGACAGTTGCCACACATTCCCCAAGCAC AAAAGGTGGAGATGGCAGTCACTTTGTAAATATGCTGTAGTCACTTATCATCTTTTCAAAGGGTAACAA GAGAATCTAAGATGTAGTAAGAATGTAAACCAGTACACTATGAGACCTAAAAGAGAGTATTAAATGTGA ACTTTTAGCAGAGCGTGGTGGCTCACACCTATAATCCCAGCGCTTTGGAGGCTGAGGTTGGAGGATTGC TTAAGTCCAGGAGTTCAAGACCAGCCTGGGTAACATGGGGTGGAACAAGCCTGTAGTCCCAGATACTCA GGAGGCTGAGGTGAAAGGATTGCTTGAGCCAGGGAGGTCAAGGCTGCAGTGAGCCGTGAAAGGCCACTG CACTCCAGCCTGAGTGACAGAATGAGACCTTGTCTCAAAAAAAAAAAAAAGTTTCTTGGAACCTATACG GTTTTTTTTTGTTTTTTTTTTTTGAAAAGCCAGACCTTGTGCCCTTGTTTTGAACACCGACTGGGAAGA TGGGGCTTAGGTAACAGCCAAACCTGGCTGTCAGCTGTGTGGGAGCCACCACCCTCTCTGGGAAGAGTT CCTGCTTCTGTATGGCAAGCATAAATCAAGCTCAGTCTGGGTTATGGAGAAGTTGAAAATTGTTTTGTT CCTCATTAGTTTATAATTGTATGAAATACGATTTTAATGAAAACTTTTCAGAATTCACGTTTGTGTAGA TATTTCAGAGAACCATTTTTACTTTACATCCTAAAACTGCCTTTTCCTATGGTTTTGTCAATAAAACAC TATGATGTT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_017520.4
Synonyms	HSMPP8; mpp8; TWA3
Summary	Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602).[UniProtKB/Swiss-Prot Function]
Locus ID	54737
MW	60.9

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