INSIG1 (NM_198336) Human 3' UTR Clone

Specifications

Product Data
Product Name	INSIG1 (NM_198336) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CL6
ACCN	NM_198336
Insert Size	1907 bp
Sequence Data	Insert Sequence (showhide) >SC216888 3’UTR clone of NM_198336 The sequence shown below is from the reference sequence of NM_198336. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GATTATGACAAAGATTATCTTTTTTCTTAAGTAATCTATTTAGATCGGGCTGACTGTACAAATGACTCC TGGAAAAAACTCTTCACCTAGTCTAGAATAGGGAGGTGGAGAATGATGACTTACCCTGAAGTCTTCCCT TGACTGCCCGCACTGGCGCCTGTCTGTGCCCTGGAGCATTCTGCCCAGGCTACGTGGGTTCAGGCAGGT GGCAGCTTCCCAAGTATTCGATTTCATTCATGTGATTAAAACAAGTTGCCATATTTCAAAGCCTTGAAC TAAGACTCAATTACCAACCCGCAGTTTTGTGTCAGTGCCCAAAGGAGGTAGGTTGATGGTGCTTAACAA ACATGAAGTATGGTGTAATAGGAATAATATTTATCCAAAAGATTTTTAAAAATAGGGCTGTGTTTAAAA AAAAAAACAAAACAAGAAAAGCAGCAGTGATTATAGAGAGGTCACACTCTAAGTGGGGTCGCGGCGTGG CCACGCTTCACGGTCACGCTCGTCCGTCCTGCAGTGGCGTGTTTACATGGTCACACGTGTGTGTATCAC CAGTGGGTCAACTGCTTGTCATTCCTCCCGTGGCAGTTTGTGTAGACAATCTTACTGAGCAAAAGGCAA TGAAAAGTCTTGGTTCCCACACTGCGATATATTGGAATTTTCACCTCAGTTTATGAAGTTTATTTCGAA ATCCATAGTCATCTAAGAATGAATACCTGTCTGCCATGTATTTCAATCTTAGTGAGCCAAAATTGTTTG TTTGTTACTACAGAATAGAGATGACTGTTTTTTGCCACAGCCCTATGGAATTTGCAATCTGTGATTGCC TTGTAAAAAGGAGAGTGCATATGGCACTGCATTAAACGTGTGGTGTTTCTAGTCAATGATATTGGTGAG CACAATGTATTCATTTAATGGCATAGACCATACCAGACCTAATTTGCAAGTATTGGGTCTTAAACTTCA AGTGCAATGTATATGAAAACCAATCTGAGCCTTGTATCTCTTAAATATTTATTTTTTTTAACGTGTGAG ATGTTCGAGAGAAGGTTCTCCATTCATTTCAGTGCTGCCTGGAGGAAACTCGGCAATGATTTCTTTCAG TTGTGAAGTTCCTTTCGTGTTACACCCTCCACTGAACCCTCAACCTTCGAAATACTCCAGTTTTGTGGG TTTGGTCATTTTTACTTATAAATTTACCTTTTTGTATTTTGCAATTTACATGTGTTTGGTTTGTTTTAA ATTCTGTGAAAGTGGCTTGATTAAAAGACTCCTTTTAAATGGAAGCCACCAGTCAGCAGAATGGAAGCT TAGAGGAACTTGCCTGTGAGCGCTGGTCTTTGTGTTTGGTTTTGTGATGTAACGATCTTTGCTGGGGTT TTTTGCTTTGTTTTGAGGGAAATGTCTTGGAGTAAATTTTAAGTTCCTGGAGTTAATTTGTTTTACAGG AATTTTGTTTTTTAAAAAAATAGGATCATTCTGAACTTTGGAATGACCCCCTTATATATTTTCTGAAAA TGAAAACAGTTACATGAAAAAAATTTCCAATGAAGATGTCAGCATTTTATGAAAAACCAGAAGTTATTA GATGAAAGCAGCGAGTGAATCTTTAAAACAGACTTGATCACGCACACACAATAAGTCTTTCTCTCCGAA ACCGGAAGTAAATCTATATCTGTTAGAAATAATGTAGCCAAAAGAATGTAAATTTGAGGATTTTTTTGC CAATAGTTTATAGAAAATATATGAACCAAAGTGATTTGAGTTTGTAAAAATGTAAAATAGTATGAACAA AATTTGCACTCTACCAGATTTGAACATCTAGTGAGGTTCACATTCATACTAAGTTTTCAACATTGTGTT CTTTTTGCATTCATTTTTTACTTTTATTAAAGGTTCAAAACCAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_198336.4
Synonyms	CL6
Summary	This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Locus ID	3638
MW	74.5

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