Hamartin (TSC1) (NM_000368) Human 3' UTR Clone

Specifications

Product Data
Product Name	Hamartin (TSC1) (NM_000368) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	LAM; TSC
ACCN	NM_000368
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC222100 3’UTR clone of NM_000368 The sequence shown below is from the reference sequence of NM_000368. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TACAATGAGACTCATCATGAACACAGCTAAGGAATGATGGTCAATCAGTGTTAACTTGCATATTGTTGG CACAGAACAGGAGGTGTGAATGCACGTTTCAAAGCTTTCCTGTTTCCAGGGTCTGAGTGCAAGTTCATG TGTGGAAATGGGACGGAGGTCCTTTGGACAGCTGACTGAATGCAGAACGGTTTTTGGATCTGGCATTGA AATGCCTCTTGACCTTCCCCTCCACCCGCCCTAACCCCCTCTCATTTACCTCGCAGTGTGTTCTAATCC AAGGGCCAGTTGGTGTTCCTCAGTAGCTTTACTTTCTTCCTTTCCCCCCCAAATGGTTGCGTCCTTTGA ACCTGTGCAATATGAGGCCAAATTTAATCTTTGAGTCTAACACACCACTTTCTGCTTTCCCGAAGTTCA GATAACTGGGTTGGCTCTCAATTAGACCAGGTAGTTTGTTGCATTGCAGGTAAGTCTGGTTTTGTCCCT TCCAGGAGGACATAGCCTGCAAAGCTGGTTGTCTTTACATGAAAGCGTTTACATGAGACTTTCCGACTG CTTTTTTGATTCTGAAGTTCAGCATCTAAAGCAGCAGGTCTAGAAGAACAACGGTTTATTCATACTTGC ATTCTTTTGGCAGTTCTGATAAGCTTCCTAGAAAGTTCTGTGTAAACAGAAGCCTGTTTCAGAAATCTG GAGCTGGCACTGTGGAGACCACACACCCTTTGGGAAAGCTCTTGTCTCTTCTTCCCCCACTACCTCTTA TTTATTTGGTGTTTGCTTGAATGCTGGTACTATTGTGACCACAGGCTGGTGTGTAGGTGGTAAAACCTG TTCTCCATAGGAGGGAAGGAGCAGTCACTGGGAGAGGTTACCCGAGAAGCACTTGAGCATGAGGAACTG CACCTTTAGGCCATCTCAGCTTGCTGGGCCTTTTGTTAAACCCTTCTGTCTACTGGCCTCCCTTTGTGT GCATACGCCTCTTGTTCATGTCAGCTTATATGTGACACTGCAGCAGAAAGGCTCTGAAGGTCCAAAGAG TTTCTGCAAAGTGTATGTGACCATCATTTCCCAGGCCATTAGGGTTGCCTCACTGTAGCAGGTTCTAGG CTACCAGAAGAGGGGCAGCTTTTTCATACCAATTCCAACTTTCAGGGGCTGACTCTCCAGGGAGCTGAT GTCATCACACTCTCCATGTTAGTAATGGCAGAGCAGTCTAAACAGAGTCCGGGAGAATGCTGGCAAAGG CTGGCTGTGTATACCCACTAGGCTGCCCCACGTGCTCCCGAGAGATGACACTAGTCAGAAAATTGGCAG TGGCAGAGAATCCAAACTCAACAAGTGCTCCTGAAAGAAACGCTAGAAGCCTAAGAACTGTGGTCTGGT GTTCCAGCTGAGGCAGGGGGATTTGGTAGGAAGGAGCCAGTGAACTTGGCTTTCCTGTTTCTATCTTTC ATTAAAAAGAATAGAAGGATTCAGTCATAAAGAGGTAAAAAACTGTCACGGTACGAAATCTTAGTGCCC ACGGAGGCCTCGAGCAGAGAGAATGAAAGTCTTTTTTTTTTTTTTTTTTTTTTAGCATGGCAATAAATA TTCTAGCATCCCTAACTAAAGGGGACTAGACAGTTAGAGACTCTGTCACCCTAGCTATACCAGCAGAAA ACCTGTTCAGGCAGGCTTTCTGGGTGTGACTGATTCCCAGCCTGTGGCAGGGCGTGGTCCCAACTACTC AGCCTAGCACAGGCTGGCAGTTGGTACTGAATTGTCAGATGTGGAGTATTAGTGACACCACACATTTAA TTCAGCTTTGTCCAAAGGAAAGCTTAAAACCCAATACAGTCTAGTTTCCTGGTTCCGTTTTAGAAAAGG AAAACGTGAACAAACTTAGAAAGGGAAGGAAATCCCATCAGTGAATCCTGAAACTGGTTTTAAGTGCTT TCCTTCTCCTCATGCCCAAGAGATCTGTGCCATAGAACAAGATACCAGGCACTTAAAGCCTTTTCCTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000368.5
Synonyms	LAM; TSC
Summary	This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018]
Locus ID	7248
MW	75.7

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