Dclre1b (NM_001025312) Mouse Untagged Clone
CAT＃: MC202656
Dclre1b (untagged) - Mouse DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae) (Dclre1b), transcript variant 2, (10ug)
CNY 3656.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | AI452214; Apollo; mSNM1B; SNMIB |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC067017 sequence for NM_001025312
GTTGGGCGCTTTCATCCTGATCGTCCCGAGCGCGGCCACCTTCTTTTTTCTCACTCTGTCTACTAATTCC GTTTCTGGGATGGTTTTCCTTTAGGGCTTCTGGACTTGTTCCAGAGTCCACTTGTCATTGGGACGCTGTC GTGGAAACCTCACTCAGGAGTGCGGTTCCCGCGAAGACCCCACTGGGTGACACCTCAACTCTGCCACCAT GAACGGGGTCGTAATCCCCCAAACGCCCATTGCTGTGGACTTTTGGAGCCTGCGCCGTGCCGGTTCGGCG CGGCTCTTCTTCTTAACCCACATGCACTGTGACCACACGGTGGGTTTGTCTAGCACTTGGGCCCGGCCCC TCTACTGCTCTCCCATCACTGCTTGCCTCTTGCATCGTCGCCTGCAGGTGATTTTCGATATACACCATCC ATGCTGAAGGAACCTGCTCTGATACTGGGGAAACAGATTCATACTTTGTATCTAGACAACACTAATTGCA ATCCAGCCCTGGTTCTTCCTTCCCGACAAGAGGCTACTCAGCAGATTGTCCAGCTAATCCGACAGTTCCC ACAACACAACATAAAAATTGGACTCTATAGTCTAGGAAAAGAATCACTGCTGGAGCAACTAGCCCTTGAG TTTCGGACCTGGGTGGTATTAAGTCCTCAACGCCTGGAGTTGGTACAGTTGCTGGGCCTGGCAGACGTGT TCACAGTTGAGGAAGAAGCCGGGCGCATCCATGCTGTGGACCATACGGAGATCTGCCACTCTGCCATGCT TCAGTGGAACCAGAGTCACCCTACCATTGCTATTTTCCCCACAAGCCGGAAAGTGCGCAGCCCTCACCCC AGCATCTACACCGTCCCGTACTCTGACCATTCATCTTACTCCGAGCTCCGTGCTTTTGTGGCAGCGCTGA GGCCTTGTCAGGTGGTGCCCATCGTCCATCAAAAGCCTTGTGGAGAGTTCTTTCAGGACAGCTTGAGTCC TAGGCTCGCTATGCCTCTGATTCCACACTCTGTGCAGCAGTACATGAGTTCCTCCTCTAGGAAAACAAAT GTGCTTTGGCAGTTAGAAAGGAGGCTCAAGAGGCCAAGAACTCAGGGTGTTGTGTTTGAATCCCCTGAGG AGAAAGCTAATCAGGTTAAAGTTGACAGAGACTCAAAGAAGCACAAAAAGGAAAACCTCTCTCCCTGGGC TGGGCACCTTGAGAGGCTTTGCCCCCATCCTCTGCAGGCCAGGAAGCAGTTGTTCCCAGACTTCTGCAGG AAAGAACGTGATGAGCCAGTCCTCTTTTGTGACTCCAACAAGATGGCGACTGTGTTGACTGCCCCACTGG AATTCTCAGTGCAATTACAACCTATAGATGAGTTTCTCTTTCCAGAAACCAGGGAGAAAATTGGCTTAGA GTCCCCATTGCTGTCAAGGGGAGACAGTGGCTCACCAGCGAGAGGGAACCAAAGTGACTGCGTAGGCTGT GGTTCTCCCCCGGCTCACATTAGCAGAGCTGTTCCTCTAACTCCTGAGTCCAGGGGCCTGGCGCTAAAAT ACCTTCTCACTCCAGTGCATTTCCTCCAAGCAGGCTTCTCTTCCAGGAACTTCGACAAGCAAGTGGAAAA ACACCAGAGAGTACAGCGTAGCAGTCCTGCAGTTCTGAGCCCGGTGGATGTTGGCTAGTGACAGGAGGTG GCTTGCTGTCTTCTTTTAAAAGAACCCTGGGGCTCACCCCAGCAGCTCTTCTGAAGCTTTTCATGAAGTC CTAGTGCCTATGAGACCCGTAGCTTTATAGTACACTATATTGTTTATTTTAATTTTATTATATTTAAGAA ACAGATTTCATTATAAACTATTCAGTGTTCATAAGCACATTAAAAGTTCTAAGAAGTTCCATAGCAATTT AATTTGTTCCACTTGGTTTAACCCAGTTTTTCTCAAACCTTTATCAACATGCAGTTCGTTTTGTTTTTTG TTTTGTTTTGTTTGAGTGGAAAAAATAGAGTCTGAATCAAAAAGAACCAGTATATTGTTATTAAATTTGT CCTGTCCCCATCCTCAAGTCCCAGATAAAAGATGTCGGTTATTTGTTTTCAGATTGTAATTCATGGTGCT GGAGGATAAAGTAGGAGTCCTGTTCTAACCCTGACTGTCACTGACTTGCTGTGACATGACCCTAACCAAG GAACTTCCTGTCTTTGCCTCTCGGAGCGAACAGGAAACCATGAAGAGGCACTGAAACAGTGTTAGGAAAA TAACACCTTCCTTCTTCATGAAGGGGTTTCGTAACTGTCATGAGACATCCATCTGGAACATAGCCATTTG GAGGTTAGGCACCACGCACCAAGGGGGTACACGGAATAAGCTGAACATTAAGGGTTAGAGTATGTCAGAG CTACTGGATGCTTGGAGACACTACTTTGTTAAAGCTACAGGGATCAAATGTGCTGCCAGATATTCTCCAA TTGTTCACATAGCTGGGATTTTCCCCCCACCCCCACAAGTTTGAATTAGGGAGCCAGAGCACAGAGCTTG TTTGTTTTAGTATCCAGGGGAGAGACCAAGGAGCCAGCTGGCTGGAACGGGTCAGAGTGTGCAGTTCTAC CCTGTCCTGCTCATAACCTGACAAAATGCCAAACCAATAAGCAAGACAGCTGATAGCACAGCCATGAGGA AATGCGGTCTGGGAGGGTGCAGGCGAGGAACGGCCTGGGCCTGGAACCTTGAGCCATAGCAGTAAAGAAA GCCATCTCTTACCCTTGGGGAGGAGGGAGGAGCTTTGCTACTTTAGGAGGGAGAAGTGAAGTTTAGTGAG CAAAATAAGACTTTGCTCTTGGACACGCTGTACTCAGTTCTGTTTTTGTCAGTGACCTTACAAACCTCTA AGGGCTTCATAGGAACTGCAGCAGGTGAGGCATGTGGTTCAACAGGAAACCTGGACATTGGCTGGCTGGA ATCCAGGGCACATGGCAAATTGTTTAAATAGAGGAGCCTTACTCAGCTGTAATGTGGGGGCTGGGATGCC TACCTCTCATGATTGCTATACAGATTATTGGTAAAATTCCCTAGTTCATTGCCTGGCACATGATTGGTTT TCGTAGCTAAAGGTGTAGCTTTGGTAGGATGTGTGTTTAGCAAGCTGAAGTCTTGGGTTCTATCCTGAGT TGTGTCCCCCCCCCCCCAAAAAAAAGCCTTTGATCTTCTCTATGAGAATACAAAGTAAAATGTCTTCCAT GTAGACTAGTTAATGGGCATTTTTTTTCTAGTCTTTCTGAGGATATAAATGTTAGATTTATACATTTTCA GAATTAGGATAATTTACATGTGTGTGTTACATGTGTGTGTACACACAAAGGGTGCTGAACAGATGGCCCA GTGGTTAAGAGCTCTTAATGTGCTCTTGAAGAAAACCTAGGTTTGGTTTCCAGCACCAACATCAAATTGA TCATAACTCAAGTTCCTCAGGTCTGATGCCTTCTGACCTCTGAACAACTGCACACAACTCATACAGTCTC ACACAATACACATAAATAAAAATAATTTTAAGTAATGTTTTTAAAAGATGTATTTGTTTATTTTATGTAT TCATATACACTGTCACTGTCTTCTGAGACACCAGAAGAGGGCATCAGATCCTATTCCAGGTGGTTGTGAC CCACCATGTGGTTGCTGGGATTTGAACTCAGGACCTCTGGATGAGCAGTCAGTGCTCTTAACCACTGAGC ACTCCAGCCCTTAAATAATGTTTTAAAGGGCCAGTGAGATGGCTTAGTGGGTAAAAGCACTTGCCACATA AACTGGTGAGCTGGATTCAATCCCTAGAGCCCACATAAAAATGGAAAAGGAGATCTGAGTGCATAAGGTT GTCCTTTGGCTGCCATGCTTGCCTATAAACAGTACTAAAAAGGGGTGGGTAAGAATAATACTGTATATGA TTTTAGATTCTGCATTTTACTTAATTCCTTAATTGGAACTCAAAATGCCATTATCAAAAAATGCTTACCC AAAAGGATGTAACTACATGTTAATAAATCATTCTCATTCAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | AscI-NotI |
| ACCN | NM_001025312 |
| Insert Size | 1248 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC067017, AAH67017 |
| RefSeq Size | 4052 bp |
| RefSeq ORF | 1248 bp |
| Locus ID | 140917 |
| UniProt ID | Q8C7W7 |
| Gene Summary | 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG206564 | Dclre1b (tGFP-tagged) - Mouse DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae) (Dclre1b), transcript variant 2 |
CNY 3140.00 |
|
| MR206564 | Dclre1b (Myc-DDK-tagged) - Mouse DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae) (Dclre1b), transcript variant 2 |
CNY 3656.00 |
|
| MR206564L3 | Lenti ORF clone of Dclre1b (Myc-DDK-tagged) - Mouse DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae) (Dclre1b), transcript variant 2 |
CNY 4750.00 |
|
| MR206564L4 | Lenti ORF clone of Dclre1b (mGFP-tagged) - Mouse DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae) (Dclre1b), transcript variant 2 |
CNY 4750.00 |
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