Mxra8 (NM_024263) Mouse Untagged Clone
CAT＃: MC202990
Mxra8 (untagged) - Mouse matrix-remodelling associated 8 (Mxra8), (10ug)
CNY 5488.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 1200013A08Rik; 1700095D18Rik; AI131686; Asp3; Dicam |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC026438
GCGGGTGCTGGCAGGGAGAGGGGGTCGGCTGTTTTTCTGGAGAGTTAGAGCTGAGTAAGACAAAGCACGT CCCCCGCAGGCGCCATGGAACTGCTGTCCCGTGTCCTGCTGTGGAAACTGCTGCTTCTTCAGAGCTCTGC AGTCCTGTCCTCAGGGCCTTCAGGGACCGCAGCAGCCAGCAACTCTCTGGTGTCTGAGTCTGTGGTGAGC TTGGCAGCCGGAACCCAGGCTGTGCTACGCTGCCAGAGCCCCCGCATGGTGTGGACCCAAGACCGGCTGC ATGATCGCCAGCGCGTGGTCCACTGGGACCTCAGCGGGGGCCCGGGCAGCCAACGGCGCCGACTTGTGGA TATGTATTCGGCGGGTGAACAGCGCGTGTACGAGCCGCGCGATCGCGACCGCCTCCTGCTGTCGCCTTCT GCTTTCCACGACGGCAACTTCTCGCTGCTCATTCGCGCTGTGGAGAGAGGCGATGAAGGGGTGTACACCT GCAACCTGCACCATCACTACTGCCACCTCGATGAGAGCCTGGCTGTGCGCCTCGAGGTTACAGAGGATCC CCTATTAAGTCGCGCATACTGGGACGGTGAGAAGGAAGTGTTGGTGGTGGCCCATGGCGCGCCGGCACTG ATGACCTGCATCAACCGTGCGCACGTGTGGACTGACCGCCATTTAGAGGAGGCGCAGCAGGTGGTCCATT GGGACCGACAGCTACCTGGAGTGTCACACGACCGCGCCGACCGCCTGCTTGACCTGTATGCATCTGGCGA GCGCCGCGCCTATGGGCCGCCCTTCCTGCGTGATCGCGTGTCAGTGAACACCAACGCTTTTGCACGCGGT GACTTCTCCCTACGCATCGATGAGCTGGAGCGAGCTGATGAGGGCATCTATTCCTGCCACCTGCACCATC ACTACTGTGGCCTCCACGAGCGCCGAGTCTTCCACCTACAGGTCACAGAGCCTGCCTTTGAGCCACCAGC TCGTGCTTCTCCTGGCAATGGGTCTGGTCACAGCAGTGCTCCTAGCCCAGATCCCACCCTGACCCGAGGC CACAGCATCATCAATGTCATTGTCCCAGAGGACCACACACATTTCTTCCAGCAACTGGGCTACGTGTTGG CCACGCTGCTGCTCTTCATCTTGCTGCTCATCACTGTAGTCCTGGCTACACGACATCGTCACAGCGGAGG ATGCAAGACGTCGGACAAAAAAGCTGGGAAGTCAAAGGGGAAGGATGTGAACATGGTGGAGTTTGCTGTA GCCACAAGGGATCAGGCTCCATATAGGACTGAGGACATCCAGCTAGATTACAAAAACAACATCCTGAAGG AGAGGGCTGAGCTGGCCCATAGTCCTCTGCCTGCCAAGGATGTGGATCTGGATAAAGAGTTCAGGAAGGA GTACTGCAAATAAATGGACCCTGAGCTTCTGGCTGGGCCAGCAGCTCTGTATCAAAGGACATCTCCCTGA CCCTCCTGCGGTATTCCTGGCTCTTCTCAGCGGCTGGTCCGACTTACCTAGAAACTTGGCCTAAACTTGG CAGAGCAGCTGCCTGTACTTTGCCCTTCCTAGAATCGCCACCCCTCATCTTGGTGAGCAACTGTGGGTTC CCTAGAGACTCTGGTATAGTACGATTGCTGCCCTTCAGTCACCTGTGCCCACTGATGGTCGTACCCCCAA CTTAAACACAACAAAGATCCCTTGTTAATATCCACCAAATGCAAAGTCCCTCGTGGCCTCTTACTGCTAG GGTCAGGAAGACACTTAAAAATTCCAGGTAAGACTCCCTAGCCACCAGTTAAACACATTAGCCATTGTCC TGGGGGGGGGTCTTCCTGAGCTGCATCGTGCCTGTGTACTGCTCAGAGCCCTGCTGTTATAGGTTCTGAC TCATGGGCCCGCCTTGCTGCTTTGGGCAACTTGAGGCTAGCCCAGGGCCCTTTCTCTGCTTCTGATTCCT TTCTGCCCAATGCCTCCCAAGAGCTACACCAGCAGTTACTGGGTACCGTATGACCCTTGGCCTTGACATC CCTCCCTAGGCTGGAGTCTGGGGTTGGGGCCCCATTTGTCCTCTGTTTTGGCTGAAGATGGGGTGAAGAT TTGGCTGAGTGGCCTATGCTGTCACATCAAACAGCTATCATTTACTCCTACTTGGGAAGTTTTCATGTGA CAATAAAAGATACATCTGAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_024263 |
| Insert Size | 1329 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC026438, AAH26438 |
| RefSeq Size | 2207 bp |
| RefSeq ORF | 1329 bp |
| Locus ID | 74761 |
| UniProt ID | Q9DBV4 |
| Gene Summary | Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity). May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MC218749 | Mxra8 (untagged) - Mouse matrix-remodelling associated 8 (Mxra8), (10ug) |
CNY 6940.00 |
|
| MG216521 | Mxra8 (tGFP-tagged) - Mouse matrix-remodelling associated 8 (Mxra8), (10ug) |
CNY 7088.00 |
|
| MR216521 | Mxra8 (Myc-DDK-tagged) - Mouse matrix-remodelling associated 8 (Mxra8) |
CNY 5488.00 |
|
| MR216521L3 | Lenti ORF clone of Mxra8 (Myc-DDK-tagged) - Mouse matrix-remodelling associated 8 (Mxra8) |
CNY 6270.00 |
|
| MR216521L4 | Lenti ORF clone of Mxra8 (mGFP-tagged) - Mouse matrix-remodelling associated 8 (Mxra8) |
CNY 6270.00 |
