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Tardbp (NM_145556) Mouse Untagged Clone
CAT＃: MC204478
Tardbp (untagged) - Mouse TAR DNA binding protein (Tardbp), transcript variant 1, (10ug)
CNY 2,000.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 1190002A23Rik; C85084; TDP-43; Tdp43 |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC025544
CCACGCGTCCGCGGAGCGGTAGCGCGGCTGTTGTCGGATTCCTTCCCGTCTCTGCTTCCTCCTTGTGCTT CCTAGCAGTGGCCTAGCGGATTTAAGCAAAGATGTCTGAATATATTCGGGTAACAGAAGATGAGAACGAT GAACCCATTGAAATACCATCAGAAGACGATGGGACGGTGTTGCTGTCCACAGTTACAGCCCAGTTTCCAG GGGCATGCGGCCTGCGCTACCGGAATCCCGTGTCTCAGTGTATGAGAGGAGTCCGACTGGTGGAAGGAAT TCTGCATGCCCCAGATGCTGGCTGGGGCAATCTGGTATATGTTGTCAACTATCCCAAAGATAACAAAAGG AAAATGGATGAGACAGATGCTTCCTCTGCAGTGAAAGTGAAAAGAGCAGTCCAGAAAACATCTGACCTCA TAGTGTTGGGTCTCCCCTGGAAAACAACTGAGCAGGATCTGAAAGACTATTTCAGTACTTTTGGAGAGGT TCTTATGGTTCAGGTCAAGAAAGATCTTAAAACTGGTCACTCGAAAGGGTTTGGCTTTGTTCGATTTACA GAATATGAAACCCAAGTGAAAGTAATGTCACAACGACATATGATAGATGGGCGATGGTGTGACTGTAAAC TTCCCAACTCTAAGCAAAGCCCAGACGAGCCTTTGAGAAGCAGAAAGGTGTTTGTTGGACGTTGTACAGA GGACATGACTGCTGAAGAGCTTCAGCAGTTTTTCTGTCAGTATGGAGAAGTGGTAGATGTCTTCATTCCC AAACCATTCAGAGCTTTTGCCTTCGTCACCTTTGCAGATGATAAGGTTGCCCAGTCTCTTTGTGGAGAGG ATTTGATCATTAAAGGAATCAGCGTGCATATATCCAATGCTGAACCTAAGCATAATAGCAATAGACAGTT AGAAAGAAGTGGAAGATTTGGTGGTAATCCAGGTGGCTTTGGGAATCAGGGTGGGTTTGGTAACAGTAGA GGGGGTGGAGCTGGCTTGGGAAATAACCAGGGTGGTAATATGGGTGGAGGGATGAACTTTGGTGCTTTTA GCATTAACCCAGCGATGATGGCTGCGGCTCAGGCAGCGTTGCAGAGCAGTTGGGGTATGATGGGCATGTT AGCCAGCCAGCAGAACCAGTCGGGCCCATCTGGGAATAACCAAAGCCAGGGCAGCATGCAGAGGGAACCA AATCAGGCTTTTGGTTCTGGAAATAATTCCTACAGTGGTTCTAATTCTGGTGCCCCCCTTGGTTGGGGGT CAGCATCAAATGCAGGATCGGGCAGTGGTTTTAATGGGGGCTTTGGCTCGAGCATGGATTCTAAGTCTTC TGGCTGGGGAATGTAGGTGGTGGGGGGTGGTTAGTAGGTTGGTTATTAGGTTAGGTAGATTTAGAATGGT GGGATTCAAATTTTTCTAAACTCATGGTAAGTATATTGTAAAATACATATGTACTAAAATTTTCAGATTG GTTTGTTCAGTGTGGAGTATATTCAGCAGTATTTTTGACATTTTTCTTTAGAAAAAAAGAGGGGAAAGCT AAATGAATTTTATAAGTTTTGTTATATAAAGGGTTAAAATACTGAGTGGGTGAAAGTGAACTGCTGTTTG CCTAATTGGTAAACCAACACTACAATTGATCTCAGAAGGTTTCTCTGTAATATTCTATCATTGAAATTGT TAATGAATTCTTTGCATGTTCAGAGTAGAAACCATTGGTTAGAACTACATTCTTTTCTCCTTATTTTAAT TTGAATCCCACCCTATGAATTTTTTCCTTAGGAAAATCTCCATTTGGGAGATCATGATGTCATGGTGTTT GATTCTTTTGGTTTTGTTTTTAACACTTGTCTTCCTTCATATACGAAAGTACAATATGAAGCCTTCATTT AATCTCTGCAGTTCATCTCATTTCAAATGTTTATGGAAGAAGCACTTCATTGAAAGTAGTGCTGTAAATA TTCTGCCATAGGAATACTTCTGTCTACATGCTTTCTCATCCAAGAATTCGTCATCACGCTGCACAGGCTG CGTCTTTGACGGTGGGTGTTCCATTTTTATCCGCTACTCTTTATTTCATGGAGTCGTATCAACGCTATGA ACGCAAGGCTGTGATATGGAACCAGAAGGCTGTTTGAACTTTTGAAACCTTGTGTGGGATTGATGGTGGT GCCGAGGCATGAAAGGCTAGTATGAGCGAGAAAAGGAGAGCGCGTGCAGAGACTTGGTGGTGGAAAATGG ATATTTTTTAACTTGGAGAGATGTGTCACTCAATCCTGTGGCTTTGGTGAGAGAGTGTGCAGAGAGCAAT GATAGCAAATAACGTACGAATGTTTTACATCAAAGGACATCCACATCAGTTGGAAGACTTTGAGTCTTGT TCTTAGGAAACCCACTTTAGTTGAATGTGTTAAGTGAAATACTTGTACTTCCCTCCCCCTCTGTCAACTG CTGTGAATGCTGTATGGTGTGTGTTCTCCTCTGTTACTGATCTGGAAGTGTGGGAACGTGAACTGAAGCT GATGGGCTGCGAACATGGACTGAGCTTGTGGTGTGCTTTGCAGGAGAACTTGGAAGCAGAGTTCACCAGT GAGCTCAGGTGTCTCAAAGAAGGGTGGAAGTTCTCATGTCTGTTAGCTATTCATAAGAATGCTGTTTGCT GCAGTTCTGTGTCCTGTGCTTGGATGCTTTTTTATAAGAGTTGTCATTGTTGGAAATTCTTAAATAAAAC TGATTTAAATAATATGTGTCTTTGTTTTGCAGCCCTGAATGCAAAGAATTCATAGCAGTTAATTCCCCTT TTTGACCCTTTTGAGATGGAACTTTCATAAAGTTTCTTGGCAGTAGTTTATTTTGCTTCAAATAAACTTA TTTGAAAAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_145556 |
| Insert Size | 1245 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | BC025544, AAH25544 |
| RefSeq Size | 2908 bp |
| RefSeq ORF | 1245 bp |
| Locus ID | 230908 |
| UniProt ID | Q921F2 |
| Gene Summary | RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3' UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3' UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival. Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins. Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG206534 | Tardbp (tGFP-tagged) - Mouse TAR DNA binding protein (Tardbp), transcript variant 1 |
CNY 3,140.00 |
|
| MR206534 | Tardbp (Myc-DDK-tagged) - Mouse TAR DNA binding protein (Tardbp), transcript variant 1 |
CNY 2,850.00 |
|
| MR206534L3 | Lenti ORF clone of Tardbp (Myc-DDK-tagged) - Mouse TAR DNA binding protein (Tardbp), transcript variant 1 |
CNY 4,750.00 |
|
| MR206534L4 | Lenti ORF clone of Tardbp (mGFP-tagged) - Mouse TAR DNA binding protein (Tardbp), transcript variant 1 |
CNY 4,750.00 |
