Trex1 (NM_011637) Mouse Untagged Clone
CAT＃: MC209585
Trex1 (untagged) - Mouse three prime repair exonuclease 1 (Trex1), transcript variant 1, (10ug)
CNY 3990.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | AU041952 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_011637 |
| Insert Size | 945 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_011637.6, NP_035767.4 |
| RefSeq Size | 1074 bp |
| RefSeq ORF | 945 bp |
| Locus ID | 22040 |
| UniProt ID | Q91XB0 |
| Gene Summary | Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG204492 | Trex1 (tGFP-tagged) - Mouse three prime repair exonuclease 1 (Trex1), transcript variant 1 |
CNY 5200.00 |
|
| MR204492 | Trex1 (Myc-DDK-tagged) - Mouse three prime repair exonuclease 1 (Trex1), transcript variant 1 |
CNY 3600.00 |
|
| MR204492L3 | Lenti ORF clone of Trex1 (Myc-DDK-tagged) - Mouse three prime repair exonuclease 1 (Trex1), transcript variant 1 |
CNY 4750.00 |
|
| MR204492L4 | Lenti ORF clone of Trex1 (mGFP-tagged) - Mouse three prime repair exonuclease 1 (Trex1), transcript variant 1 |
CNY 4750.00 |
