Fbxo11 (NM_001081034) Mouse Untagged Clone
CAT＃: MC222715
Fbxo11 (untagged) - Mouse F-box protein 11 (Fbxo11), (10ug)
CNY 11970.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | C80048; Jf |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC222715 representing NM_001081034
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGAACTCCGTCCGAGCCGCCAACCGGAGACCCAGGCGAGTGTCGCGGCCGCGCCCGGTGCAACAGCAGC AGCAGCAGCCCCCGCAGCAGCCGCCGCCGCAGCCGCCTCAGCAACAGCCGCCGCCGCAGCCGCCCCAGCA GCCGCCGCAGCAGCAGCCCCCGCCGCCGCCGCAGCAGCAGCCCCCGCCGCCGCCCCCGCCGCCTCCGCCG CCGCCTCAGGATCGGAACAACGCCGGCGAGAGGGATGATGTTCCTGCAGATATGGTTGCAGAAGAATCAG GTCCTGGTGCACAAAATAGTCCATACCAACTTCGCAGAAAAACTCTTTTGCCAAAAAGAACAGCGTGTCC TACAAAGAGCAGTATGGAGGGTGCCTCTACTTCGACTACAGAAAACTTTGGTCATCGAGCAAAGCGTGCA AGAGTGTCTGGAAAGTCACAAGATCTTTCAGCAGCACCCGCTGAACAGTATCTTCAGGAGAAGCTGCCAG ATGAAGTAGTTTTAAAAATATTTTCTTATTTGCTGGAACAAGACCTTTGTAGAGCTGCTTGCGTGTGTAA ACGCTTCAGTGAGCTTGCTAATGATCCAATTTTGTGGAAACGATTATATATGGAAGTATTTGAATATACC CGGCCGATGATGCATCCTGAACCTGGTAAATTCTACCAGATTAATCCAGAAGAATATGAACATCCAAATC CATGGAAAGAAAGTTTTCAACAGTTGTATAAAGGTGCGCATGTAAAGCCAGGATTTGCGGAACATTTCTA TAGTAATCCTGCAAGATACAAAGGAAGAGAAAACATGTTGTATTATGATACTATTGAAGATGCCCTTGGA GGAGTACAAGAAGCACATTTTGATGGGCTTATCTTTGTTCATTCTGGAATATATACTGATGAATGGATAT ATATTGAATCTCCAATTACTATGATTGGTGCAGCACCTGGCAAGGTTGCAGACAAGGTCATCATTGAGAA CACTAGAGATTCGACCTTCGTGTTCATGGAAGGCTCTGAAGATGCTTATGTTGGATACATGACGATAAGA TTCAACCCTGATGACAAATCTGCTCAGCATCACAACGCACACCACTGCTTAGAGATCACAGTCAACTGCA GCCCTATTATTGACCACTGTATAATCCGCAGCACATGCACAGTTGGTTCTGCAGTGTGTGTCAGTGGCCA GGGGGCGTGTCCCACTATCAAGCATTGTAACATCAGTGACTGTGAAAACGTCGGACTTTATATAACAGAT CATGCACAGGGAATATATGAAGATAATGAAATTTCTAATAATGCGTTAGCTGGGATTTGGGTTAAAAATC ATGGAAATCCAATTATTAGACGGAATCACATTCATCATGGACGTGATGTTGGTGTGTTCACATTTGATCA TGGCATGGGCTACTTTGAAAGTTGCAACATACACAGAAACAGGATAGCAGGCTTTGAGGTAAAAGCCTAT GCCAATCCCACAGTGGTTCGATGTGAGATTCACCACGGGCAGACTGGAGGAATATACGTCCACGAGAAAG GAAGAGGACAGTTCATAGAGAACAAGATCTATGCAAACAATTTCGCAGGCGTGTGGATTACCTCAAATAG TGACCCAACAATAAGGGGGAATTCTATATTTAATGGAAATCAAGGAGGAGTTTACATCTTTGGTGACGGA CGAGGCCTTATAGAAGGAAATGACATTTATGGTAATGCGTTAGCAGGAATTCAGATCAGGACAAACAGTT GTCCTATTGTTCGACATAACAAAATTCATGATGGACAGCATGGTGGGATTTATGTGCATGAAAAGGGGCA AGGAGTAATAGAAGAGAATGAAGTTTACAGCAACACTCTGGCTGGCGTCTGGGTGACAACTGGCAGCACA CCAGTTCTAAGAAGAAACCGGATACACAGTGGCAAGCAGGTTGGTGTTTATTTCTATGACAATGGACATG GTGTTCTAGAAGATAACGACATCTACAATCACATGTATTCAGGGGTTCAGATAAGAACTGGAAGCAACCC CAAAATTAGACGCAACAAAATTTGGGGAGGACAGAATGGTGGAATTCTAGTTTATAATTCTGGTCTAGGC TGTATAGAAGACAATGAAATATTTGACAACGCGATGGCTGGAGTCTGGATTAAAACAGATAGTAATCCTA CGCTAAGAAGAAATAAAATCCATGATGGAAGAGATGGTGGCATCTGTATATTTAATGGGGGTCGAGGTCT CCTTGAAGAAAATGATATTTTCAGGAACGCTCAAGCAGGTGTCCTCATCAGCACTAACAGTCATCCAGTA TTAAGGAAAAACAGAATATTTGATGGATTTGCTGCAGGTATTGAAATTACAAATCATGCAACTGCAACAC TCGAAGGCAATCAGATCTTTAACAACCGATTTGGAGGCTTATTTTTAGCATCTGGTGTTAATGTGACAAT GAAAGATAACAAAATAATGAACAATCAAGATGCCATAGAAAAGGCTGTTAGTAGAGGACAATGTCTATAT AAAATATCAAGTTATACCAGCTACCCCATGCATGACTTCTACAGATGTCATACTTGTAACACCACAGATC GAAATGCCATATGTGTGAACTGCATTAAGAAGTGCCATCAGGGACATGATGTAGAGTTCATTAGACATGA TAGGTTTTTCTGTGACTGTGGTGCTGGAACGCTGTCTAATCCTTGTACCTTAGCTGGCGAGCCTACACAC GACACAGACACACTCTATGACTCTGCCCCACCTATAGAATCTAATACGTTGCAGCACAACTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001081034 |
| Insert Size | 2793 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001081034.1, NP_001074503.1 |
| RefSeq Size | 4013 bp |
| RefSeq ORF | 2793 bp |
| Locus ID | 225055 |
| UniProt ID | Q7TPD1 |
| Gene Summary | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG224533 | Fbxo11 (tGFP-tagged) - Mouse F-box protein 11 (Fbxo11), (10ug) |
CNY 9030.00 |
|
| MR224533 | Fbxo11 (Myc-DDK-tagged) - Mouse F-box protein 11 (Fbxo11) |
CNY 6808.00 |
|
| MR224533L3 | Lenti ORF clone of Fbxo11 (Myc-DDK-tagged) - Mouse F-box protein 11 (Fbxo11) |
CNY 10070.00 |
|
| MR224533L4 | Lenti ORF clone of Fbxo11 (mGFP-tagged) - Mouse F-box protein 11 (Fbxo11) |
CNY 10070.00 |
