Mertk (NM_008587) Mouse Untagged Clone
CAT＃: MC222992
Mertk (untagged) - Mouse c-mer proto-oncogene tyrosine kinase (Mertk), (10ug)
CNY 10928.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | Eyk; Mer; nmf12; Nyk |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC222992 representing NM_008587
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGTTCTGGCCCCACTGCTACTGGGGCTGCTGCTGCTACCCGCGCTCTGGAGTGGAGGCACTGCCGAGA AGTGGGAAGAGACCGAGCTAGATCAGCTATTTTCAGGGCCTTTACCAGGGAGACTCCCAGTCAACCACAG GCCATTCTCTGCTCCTCACTCCAGCCGGGACCAGCTGCCACCACCCCAGACTGGAAGATCACATCCAGCA CACACAGCCGCTCCCCAGGTGACCTCCACAGCATCAAAGCTCCTACCTCCTGTTGCGTTTAATCACACCA TTGGACACATAGTACTGTCGGAACATAAAAATGTCAAATTTAATTGCTCCATCAATATTCCTAACACATA CCAAGAAACAGCTGGCATTTCATGGTGGAAAGATGGAAAGGAATTGCTCGGGGCACATCATTCAATCACA CAGTTTTATCCTGATGAGGAAGGGGTATCAATAATTGCATTGTTCAGCATAGCCAGTGTGCAGCGCTCAG ACAATGGGTCGTACTTCTGTAAGATGAAGGTGAACAATAGAGAGATTGTATCTGATCCCATATACGTGGA AGTTCAAGGACTCCCTTACTTTATTAAGCAGCCTGAGAGTGTGAATGTCACCAGAAACACAGCCTTCAAC CTCACCTGCCAGGCCGTGGGCCCTCCTGAGCCCGTCAATATCTTCTGGGTTCAAAATAGCAGCCGTGTTA ATGAAAAACCGGAAAGGTCCCCGTCTGTCCTAACCGTACCTGGTCTGACAGAGACAGCAGTCTTCAGCTG TGAGGCCCACAATGACAAAGGACTGACGGTGTCCAAGGGTGTACATATCAACATCAAAGTAATCCCCTCC CCGCCCACTGAAGTCCATATCCTCAACAGTACAGCACACAGCATCCTGGTCTCCTGGGTCCCTGGTTTTG ATGGCTACTCCCCACTTCAGAACTGCAGCATTCAGGTCAAGGAAGCTGACCGGCTGAGTAATGGCTCAGT CATGGTTTTTAATACCTCTGCTTCGCCACATCTGTATGAGATCCAGCAGCTGCAAGCCCTGGCTAATTAC AGCATCGCTGTGTCCTGTCGGAATGAGATTGGCTGGTCTGCAGTAAGCCCTTGGATTCTGGCCAGCACAA CAGAAGGAGCTCCATCTGTAGCACCTTTAAACATCACTGTGTTTCTGAACGAATCTAACAATATCCTGGA TATTAGATGGACGAAGCCTCCAATTAAGCGGCAGGATGGGGAACTGGTGGGCTACCGGATATCTCACGTG TGGGAAAGCGCAGGGACTTACAAAGAGCTTTCTGAAGAAGTCAGCCAGAATGGCAGCTGGGCTCAGATTC CTGTCCAAATCCACAATGCCACCTGCACAGTGAGAATCGCGGCCATTACTAAAGGGGGCATCGGGCCCTT CAGTGAGCCAGTGAATATCATCATTCCTGAACACAGTAAGGTAGATTACGCACCCTCGTCAACCCCAGCC CCTGGCAACACCGACTCTATGTTCATCATCCTCGGCTGCTTCTGTGGATTCATTTTAATCGGGTTAATTT TGTGTATTTCTCTGGCCCTCAGAAGGAGAGTCCAGGAAACAAAGTTTGGGGGAGCATTCTCTGAGGAGGA TTCCCAACTGGTCGTAAATTATAGAGCGAAGAAGTCCTTCTGCCGGCGAGCCATCGAGCTTACCTTGCAG AGCCTGGGAGTGAGCGAGGAGCTGCAGAATAAGCTGGAAGATGTTGTGATTGACAGAAACCTTCTGGTTC TCGGCAAAGTTCTGGGTGAAGGAGAGTTTGGGTCTGTAATGGAAGGAAATTTGAAGCAAGAAGATGGGAC TTCTCAGAAGGTGGCAGTGAAGACCATGAAGTTGGACAACTTTTCTCAACGGGAGATCGAGGAGTTTCTC AGCGAAGCAGCATGCATGAAAGACTTCAACCACCCAAATGTCATCCGACTTCTAGGCGTGTGTATAGAAC TGAGCTCTCAAGGCATCCCGAAGCCCATGGTGATTTTACCCTTCATGAAATACGGAGACCTCCACACCTT CCTGTTATATTCCCGATTAAACACAGGACCCAAGTACATTCACCTGCAGACACTACTGAAGTTCATGATG GACATTGCCCAGGGAATGGAGTATCTGAGCAACAGGAATTTTCTTCATAGGGATTTGGCAGCTCGAAACT GCATGTTGCGGGATGACATGACTGTCTGCGTGGCAGACTTTGGCCTCTCAAAGAAGATTTACAGTGGTGA TTATTACCGCCAAGGCCGCATTGCCAAAATGCCTGTGAAGTGGATCGCCATCGAGAGCCTGGCGGACCGA GTCTACACAAGCAAAAGTGACGTGTGGGCTTTTGGCGTGACCATGTGGGAAATAACAACACGGGGAATGA CTCCCTATCCCGGAGTTCAGAACCATGAGATGTACGACTACCTTCTCCACGGCCACAGGCTGAAGCAGCC TGAGGACTGCTTGGATGAACTGTATGACATCATGTACTCTTGCTGGAGTGCTGATCCCTTGGATCGACCC ACCTTCTCTGTGTTGAGGCTGCAGCTGGAAAAGCTCTCCGAGAGTTTGCCTGATGCGCAGGACAAAGAAT CCATCATCTACATCAATACCCAGTTGCTAGAGAGCTGCGAGGGCATAGCCAATGGGCCCTCACTCACGGG GCTAGACATGAACATTGACCCTGACTCCATCATTGCCTCTTGCACACCAGGCGCTGCCGTCAGCGTGGTC ACGGCAGAAGTTCACGAGAACAACCTTCGTGAGGAAAGATACATCTTGAATGGGGGCAATGAGGAATGGG AAGATGTGTCCTCCACTCCTTTTGCTGCAGTCACACCTGAAAAGGATGGTGTCTTACCGGAGGACAGACT CACCAAAAATGGCGTCTCCTGGTCTCACCATAGTACACTACCCTTGGGGAGCCCATCACCAGATGAACTT TTATTTGTAGATGACTCCTTGGAAGACTCTGAAGTTCTGATGTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_008587 |
| Insert Size | 2985 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_008587.1, NP_032613.1 |
| RefSeq Size | 3564 bp |
| RefSeq ORF | 2985 bp |
| Locus ID | 17289 |
| UniProt ID | Q60805 |
| Gene Summary | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.[UniProtKB/Swiss-Prot Function] |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG225392 | Mertk (tGFP-tagged) - Mouse c-mer proto-oncogene tyrosine kinase (Mertk), (10ug) |
CNY 12520.00 |
|
| MR225392 | Mertk (Myc-DDK-tagged) - Mouse c-mer proto-oncogene tyrosine kinase (Mertk) |
CNY 10920.00 |
|
| MR225392L1 | Lenti ORF clone of Mertk (Myc-DDK-tagged) - Mouse c-mer proto-oncogene tyrosine kinase (Mertk) |
CNY 11780.00 |
|
| MR225392L2 | Lenti ORF clone of Mertk (mGFP-tagged) - Mouse c-mer proto-oncogene tyrosine kinase (Mertk) |
CNY 13320.00 |
|
| MR225392L3 | Lenti ORF clone of Mertk (Myc-DDK-tagged) - Mouse c-mer proto-oncogene tyrosine kinase (Mertk) |
CNY 11780.00 |
|
| MR225392L4 | Lenti ORF clone of Mertk (mGFP-tagged) - Mouse c-mer proto-oncogene tyrosine kinase (Mertk) |
CNY 13320.00 |
