Foxp1 (NM_001197321) Mouse Tagged ORF Clone

Specifications

Product Data
Type	Mouse Tagged ORF Clone
Tag	Myc-DDK
Synonyms	3110052D19Rik; 4932443N09Rik; AI461938; AW494214
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	ORF Nucleotide Sequence (showhide) >MR230847 representing NM_001197321 Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGATGCAAGAATCTGGGTCTGAGACAAAAAGTAACGGATCAGCCATCCAGAACGGGTCCAGCGGTGGCA ACCACTTACTAGAGTGCGGGGCACTTCGTGACACTCGGTCCAACGGAGAGGCACCAGCGGTGGACCTGGG GGCAGCCGACCTTGCCCACGTCCAGCAGCAGCAACAGCAGCAGCAACAACAGCAGCAGCAGCAACAGCAG CAGCAGCAGCAGCAAGTTAGTGGATTAAAGTCTCCCAAGAGGAATGACAAGCAACCAGCTCTTCAGGTTC CCGTGTCAGTGGCTATGATGACACCTCAGGTTATCACTCCTCAACAAATGCAGCAGATCCTCCAGCAGCA GGTGCTGAGCCCCCAGCAGCTCCAGGTTCTCCTCCAGCAGCAGCAGGCCCTCATGCTTCAACAGCAGCTT CAAGAATTTTATAAAAAACAACAGGAACAGTTGCAGCTTCAACTTCTCCAACAGCAACATGCTGGAAAAC AGCCGAAAGAGCAGCAGGTGGCTACCCAGCAGTTGGCTTTCCAGCAGCAGCTTCTCCAGATGCAGCAGCT GCAGCAGCAGCACCTCTTGTCTCTCCAGCGCCAAGGCCTCCTAACAATTCAGCCGGGGCAGCCTGCCCTT CCCCTCCAACCCCTCGCTCAAGGCATGATTCCAACGGAACTGCAGCAGCTCTGGAAAGAAGTGACAAGTG CCCACACTGCAGAGGAAACCACAAGCAGCAACCACAGCAGCCTAGACCTGACCAGCACATGTGTCTCGTC CTCGGCACCTTCCAAGTCCTCCCTAATCATGAACCCGCATGCCTCTACCAATGGACAGCTCTCGGTCCAC ACTCCCAAAAGGGAAAGCTTGTCCCACGAGGAGCACCCCCACAGCCACCCTCTCTATGGACATGGCGTAT GCAAGTGGCCAGGCTGTGAGGCGGTTTGTGACGACTTCCCAGCCTTTCTAAAACATCTCAACAGTGAGCA TGCGCTGGACGATAGAAGCACAGCTCAATGTAGAGTACAAATGCAGGTTGTACAGCAGTTAGAGCTACAG CTTGCAAAAGACAAAGAGCGCCTGCAAGCCATGATGACCCACCTGCATGTGAAGTCTACAGAACCCAAAG CTGCCCCTCAGCCCCTGAATCTGGTATCAAGTGTCACCCTCTCCAAGTCTGCCTCAGAGGCTTCTCCACA GAGCTTACCTCATACTCCAACAACCCCCACCGCCCCCCTGACTCCTGTCACCCAAGGCCCCTCCGTCATC ACCACCACCAGCATGCACACGGTGGGACCTATCCGCAGGCGGTACTCAGACAAATACAACGTGCCCATTT CTTCAGCAGATATTGCGCAGAACCAAGAATTTTATAAGAACGCGGAAGTTAGACCACCATTTACATATGC ATCTTTAATCAGGCAGGCCATTCTCGAATCTCCAGAAAAGCAGCTAACACTAAACGAAATCTATAACTGG TTCACACGAATGTTTGCTTACTTCCGACGCAATGCAGCCACGTGGAAGAATGCAGTGCGTCATAATCTTA GTCTCCACAAGTGTTTTGTGCGAGTAGAGAACGTTAAAGGGGCAGTATGGACAGTGGATGAAGTAGAGTT CCAAAAACGGAGGCCACAAAAGATCAGTGGTAACCCTTCCCTTATTAAAAACATGCAGAGCAGCCACGCC TACTGCACACCTCTCAATGCAGCTTTACAGGCTTCCATGGCTGAGAATAGTATACCTCTGTACACTACCG CTTCCATGGGAAATCCCACTCTGGGCAGCCTGGCCAGTGCCATCCGGGAGGAGCTGAACGGGGCCATGGA GCACACCAACAGCAACGAGAGTGACAGCAGTCCAGGCAGATCCCCTATGCAAGCTGTGCACCCCATACAC GTCAAAGAAGAACCCCTCGACCCCGAGGAAGCTGAAGGCCCTCTGTCCTTAGTGACAACAGCCAACCACA GTCCAGATTTTGACCATGACAGAGATTACGAAGACGAACCAGTAAATGAGGACATGGAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA Protein Sequence (showhide) >MR230847 representing NM_001197321 Red=Cloning site Green=Tags(s) MMQESGSETKSNGSAIQNGSSGGNHLLECGALRDTRSNGEAPAVDLGAADLAHVQQQQQQQQQQQQQQQQ QQQQQVSGLKSPKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQL QEFYKKQQEQLQLQLLQQQHAGKQPKEQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPAL PLQPLAQGMIPTELQQLWKEVTSAHTAEETTSSNHSSLDLTSTCVSSSAPSKSSLIMNPHASTNGQLSVH TPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCDDFPAFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQ LAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVI TTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNW FTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHA YCTPLNAALQASMAENSIPLYTTASMGNPTLGSLASAIREELNGAMEHTNSNESDSSPGRSPMQAVHPIH VKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene      Plasmid Map
ACCN	NM_001197321
ORF Size	2019 bp
OTI Disclaimer	Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001197321.1, NP_001184250.1
RefSeq Size	7042 bp
RefSeq ORF	2022 bp
Locus ID	108655
UniProt ID	P58462
MW	75.4 kDa
Gene Summary	Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (PubMed:11358962, PubMed:14701752). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2 (PubMed:11358962, PubMed:22675208). Essential transcriptional regulator of B-cell development (PubMed:16819554). Involved in regulation of cardiac muscle cell proliferation (PubMed:20713518). Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins (PubMed:18667151, PubMed:18662545). Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3 (PubMed:20175877). Negatively regulates the differentiation of T follicular helper cells T(FH)s (PubMed:24859450). Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (PubMed:23946441). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity).[UniProtKB/Swiss-Prot Function]

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